Cacng8 Gene Summary [Mouse]
Enables calcium channel regulator activity. Involved in regulation of AMPA receptor activity and regulation of postsynaptic membrane neurotransmitter receptor levels. Located in postsynaptic density. Part of L-type voltage-gated calcium channel complex. Is active in Schaffer collateral - CA1 synapse; glutamatergic synapse; and postsynaptic density membrane. Is expressed in central nervous system and retina. Used to study antisocial personality disorder. Orthologous to human CACNG8 (calcium voltage-gated channel auxiliary subunit gamma 8). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Cacng8 |
| Official Name | calcium channel, voltage-dependent, gamma subunit 8 [Source:MGI Symbol;Acc:MGI:1932376] |
| Ensembl ID | ENSMUSG00000053395 |
| Bio databases IDs | |
| Aliases | calcium channel, voltage-dependent, gamma subunit 8 |
| Synonyms | calcium channel, voltage-dependent, gamma subunit 8, calcium channel, voltage-dependent, γ subunit 8, calcium voltage-gated channel auxiliary subunit gamma 8, calcium voltage-gated channel auxiliary subunit γ 8, TARP gamma-8, TARP γ-8 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Cacng8 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- protein phosphatase 2B binding
- PMP-22/EMP/MP20/Claudin family
- protein binding
- ionotropic glutamate receptor binding
- ion channel
- calcium channel regulator
Pathways
Biological processes and signaling networks where the Cacng8 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
- Amyotrophic Lateral Sclerosis Signaling
- Androgen Signaling
- Calcium Signaling
- Cardiac β-adrenergic Signaling
- CCR5 Signaling in Macrophages
- Cellular Effects of Sildenafil (Viagra)
- Circadian Rhythm Signaling
- Corticotropin Releasing Hormone Signaling
- Dopamine-DARPP32 Feedback in cAMP Signaling
- FcγRIIB Signaling in B Lymphocytes
- G Beta Gamma Signaling
- GABA Receptor Signaling
- GNRH Signaling
- GPCR-Mediated Nutrient Sensing in Enteroendocrine Cells
- Gustation Pathway
- Maturity Onset Diabetes of Young (MODY) Signaling
- Netrin Signaling
- Nitric Oxide Signaling in the Cardiovascular System
- nNOS Signaling in Skeletal Muscle Cells
- PKCθ Signaling in T Lymphocytes
- Type II Diabetes Mellitus Signaling
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
role in cell
- expression in
- binding
- cell death
- depolarization
- abnormal morphology
- long-term potentiation
- paired-pulse depression in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- glutaminergic synapse
- endocytic vesicle membrane
- cell surface
- cellular membrane
- postsynaptic membrane
- synaptic membrane
- synapse
- dendrites
- postsynaptic density
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Cacng8 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- calcium ion transport
- calcium ion transmembrane transport
- regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity
- positive regulation of synaptic transmission, glutamatergic
- transmission of nerve impulse
Cellular Component
Where in the cell the gene product is active
- alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid selective glutamate receptor complex
- postsynaptic density
- voltage-gated calcium channel complex
- plasma membrane
- endocytic vesicle membrane
Molecular Function
What the gene product does at the molecular level
- calcium channel regulator activity
- voltage-gated calcium channel activity
- channel regulator activity