Cacng2 Gene Summary [Mouse]
Enables voltage-gated calcium channel activity. Involved in neurotransmitter receptor localization to postsynaptic specialization membrane and postsynaptic neurotransmitter receptor diffusion trapping. Acts upstream of or within several processes, including membrane hyperpolarization; neuromuscular junction development; and transmission of nerve impulse. Located in somatodendritic compartment. Part of AMPA glutamate receptor complex. Is active in several cellular components, including Schaffer collateral - CA1 synapse; hippocampal mossy fiber to CA3 synapse; and postsynaptic density membrane. Is expressed in several structures, including brain; genitourinary system; ileum; spinal cord; and trigeminal nerve. Human ortholog(s) of this gene implicated in autosomal dominant intellectual developmental disorder 10. Orthologous to human CACNG2 (calcium voltage-gated channel auxiliary subunit gamma 2). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Cacng2 |
| Official Name | calcium channel, voltage-dependent, gamma subunit 2 [Source:MGI Symbol;Acc:MGI:1316660] |
| Ensembl ID | ENSMUSG00000019146 |
| Bio databases IDs | |
| Aliases | calcium channel, voltage-dependent, gamma subunit 2 |
| Synonyms | B230105C07Rik, B930041E13Rik, calcium channel, voltage-dependent, gamma subunit 2, calcium channel, voltage-dependent, γ subunit 2, calcium voltage-gated channel auxiliary subunit gamma 2, calcium voltage-gated channel auxiliary subunit γ 2, Ipr328, MRD10, stargazer, stargazin, stg, TARP gamma-2, TARP γ-2, wag, waggler |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Cacng2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- voltage-gated calcium channel
- PMP-22/EMP/MP20/Claudin family
- protein binding
- ionotropic glutamate receptor binding
- PDZ binding motif
- ion channel
Pathways
Biological processes and signaling networks where the Cacng2 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
- Amyotrophic Lateral Sclerosis Signaling
- Androgen Signaling
- Calcium Signaling
- Cardiac Hypertrophy Signaling
- Cardiac β-adrenergic Signaling
- CCR5 Signaling in Macrophages
- Cellular Effects of Sildenafil (Viagra)
- Circadian Rhythm Signaling
- Corticotropin Releasing Hormone Signaling
- CREB Signaling in Neurons
- Dopamine-DARPP32 Feedback in cAMP Signaling
- Estrogen Receptor Signaling
- FcγRIIB Signaling in B Lymphocytes
- G Beta Gamma Signaling
- GABA Receptor Signaling
- GNRH Signaling
- GPCR-Mediated Nutrient Sensing in Enteroendocrine Cells
- Gustation Pathway
- Maturity Onset Diabetes of Young (MODY) Signaling
- Mitochondrial Dysfunction
- Nitric Oxide Signaling in the Cardiovascular System
- nNOS Signaling in Skeletal Muscle Cells
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- ataxia
- schizophrenia
- autosomal dominant mental retardation type 10
- complex neurodevelopmental disorder
- suicide attempt
- failure to thrive
- gait disturbance
- cleft lip
phenotypes
- abnormal AMPA-mediated synaptic currents
- abnormal CNS synapse formation
- abnormal CNS synaptic transmission
- abnormal Purkinje cell innervation
- abnormal brain wave pattern
- abnormal crista ampullaris morphology
- abnormal excitatory postsynaptic currents
- abnormal gait
- abnormal hippocampal mossy fiber morphology
- abnormal innervation
- abnormal locomotor coordination
- abnormal miniature excitatory postsynaptic currents
- abnormal motor neuron morphology
- abnormal neuromuscular synapse morphology
- abnormal neuron differentiation
- abnormal synapse morphology
- abnormal synaptic vesicle morphology
- abnormal synaptic vesicle number
- abnormal thalamus morphology
- abnormal type I vestibular cell
- abnormal vestibular hair cell morphology
- absence seizures
- ataxia
- circling
- decreased CNS synapse formation
- decreased body size
- decreased body weight
- decreased startle reflex
- decreased vertical activity
- head bobbing
- head shaking
- head tossing
- hyperactivity
- impaired coordination
- impaired righting response
- impaired swimming
- increased or absent threshold for auditory brainstem response
- loss of hippocampal neurons
- male infertility
- reduced AMPA-mediated synaptic currents
- stereotypic behavior
role in cell
- binding in
- transmembrane potential
- binding
- development
- synaptic transmission
- depolarization
- transmission
- paired-pulse depression in
- function in
- trafficking
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- postsynaptic density (PSD) fractions
- glutaminergic synapse
- endocytic vesicle membrane
- cell surface
- somatodendritic region
- postsynaptic region
- cellular membrane
- synaptic membrane
- synapse
- axons
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Cacng2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- neuromuscular junction development
- response to calcium ion
- regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity
- calcium ion transmembrane transport
- membrane hyperpolarization
- eye blink reflex
- positive regulation of synaptic transmission, glutamatergic
- membrane depolarization
- protein targeting to membrane
- transmission of nerve impulse
Cellular Component
Where in the cell the gene product is active
- alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid selective glutamate receptor complex
- voltage-gated calcium channel complex
- cerebellar mossy fiber
- endocytic vesicle membrane
- plasma membrane
- cell surface
Molecular Function
What the gene product does at the molecular level
- ionotropic glutamate receptor binding
- protein binding
- voltage-gated calcium channel activity
- channel regulator activity