Gp6 Gene Summary [Mouse]
Enables collagen binding activity and collagen receptor activity. Acts upstream of or within collagen-activated tyrosine kinase receptor signaling pathway; peptidyl-tyrosine phosphorylation; and platelet aggregation. Located in cell surface and plasma membrane. Is expressed in bone marrow; femur; liver; and spleen. Human ortholog(s) of this gene implicated in blood platelet disease (multiple); coronary artery disease (multiple); and type 2 diabetes mellitus. Orthologous to human GP6 (glycoprotein VI platelet). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Gp6 |
| Official Name | glycoprotein 6 (platelet) [Source:MGI Symbol;Acc:MGI:1889810] |
| Ensembl ID | ENSMUSG00000078810 |
| Bio databases IDs | |
| Aliases | glycoprotein 6 (platelet) |
| Synonyms | 9830166G18Rik, BDPLT11, glycoprotein 6 platelet, glycoprotein VI, glycoprotein VI platelet, Gm469, GPIV, GPVI, LOC100913068, LOC636242 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Gp6 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- extracellular domain
- signaling receptor activity
- protein kinase binding
- immunoglobulin domain
- ectodomain
- protein binding
- proline rich domain
- collagen receptor
- cytoplasmic domain
- transmembrane domain
- Immunoglobulin like
- intracellular domain
- collagen binding
- cytosolic tail domain
- transmembrane receptor
Pathways
Biological processes and signaling networks where the Gp6 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- thrombocytopenia
- bleeding
- metastasis
- thrombosis
- opioid dependence
- essential thrombocythemia
- impaired glucose tolerance
- platelet-type bleeding disorder type 11
- hypothermia
- angina pectoris
role in cell
- aggregation
- quantity
- inhibition
- phosphorylation in
- adhesion
- cell spreading
- activation
- recruitment
- secretion
- binding
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- tetraspanin-enriched microdomain
- cell surface
- cellular membrane
- membrane rafts
- plasma
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Gp6 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- immune response-regulating signaling pathway
- collagen-activated signaling pathway
- collagen-activated tyrosine kinase receptor signaling pathway
- enzyme linked receptor protein signaling pathway
- platelet aggregation
- platelet activation
Cellular Component
Where in the cell the gene product is active
- extracellular vesicular exosome
- membrane raft
- tetraspanin-enriched microdomain
- plasma membrane
- cell surface
Molecular Function
What the gene product does at the molecular level
- protein binding
- transmembrane signaling receptor activity
- collagen binding
- signaling receptor activity
- collagen receptor activity