Phf12 Gene Summary [Mouse]
Enables transcription corepressor binding activity. Predicted to be involved in negative regulation of transcription by RNA polymerase II. Predicted to be located in nucleoplasm. Predicted to be part of Sin3-type complex and transcription repressor complex. Predicted to be active in nucleus. Is expressed in several structures, including branchial arch; central nervous system; embryo mesenchyme; genitourinary system; and maxillary process. Orthologous to human PHF12 (PHD finger protein 12). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Phf12 |
| Official Name | PHD finger protein 12 [Source:MGI Symbol;Acc:MGI:1924057] |
| Ensembl ID | ENSMUSG00000037791 |
| Bio databases IDs | |
| Aliases | PHD finger protein 12 |
| Synonyms | 2410142K10Rik, F630045O13, mKIAA1523, PF1, PHD finger protein 12 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Phf12 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- PHD zinc finger
- transcription regulator
- PHD finger protein 12 MRG binding domain
- transcription co-repressor
- PHD finger superfamily
- transcription factor binding
- protein binding
- phosphatidylinositol binding
- forkhead associated (FHA) domain superfamily
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- left colon cancer
- infection by HIV-1
role in cell
- expression in
- proliferation
- proliferative capacity
- incorporation in
- morphology
- checkpoint recovery in
- mitotic entry in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- nucleoplasm
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Phf12 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of transcription from RNA polymerase II promoter
- negative regulation of transcription, DNA-dependent
Cellular Component
Where in the cell the gene product is active
- nucleus
- transcriptional repressor complex
- Sin3-type complex
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- transcription corepressor binding
- protein binding
- metal ion binding
- transcription corepressor activity
- phosphatidylinositol binding