Nap1l2 Gene Summary [Mouse]
Enables chromatin binding activity; histone acetyltransferase regulator activity; and histone binding activity. Acts upstream of or within positive regulation of neuron differentiation and regulation of stem cell division. Predicted to be active in chromatin and nucleus. Is expressed in nervous system. Orthologous to human NAP1L2 (nucleosome assembly protein 1 like 2). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Nap1l2 |
| Official Name | nucleosome assembly protein 1-like 2 [Source:MGI Symbol;Acc:MGI:106654] |
| Ensembl ID | ENSMUSG00000082229 |
| Bio databases IDs | |
| Aliases | nucleosome assembly protein 1-like 2 |
| Synonyms | BPX, nucleosome assembly protein 1-like 2 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Nap1l2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Nucleosome assembly protein (NAP)
- histone binding
- histone acetyltransferase regulator
- PTZ00007
- chromatin binding
- protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- colon cancer
- X-linked immunodeficiency with magnesium defect, Epstein-Barr virus infection and neoplasia
- Turner syndrome
- colorectal cancer
regulates
- HAT
- CDKN1C
role in cell
- differentiation
- quantity
- cell division
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- Cytoplasm
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Nap1l2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- neuron differentiation
- positive regulation of neuron differentiation
- regulation of stem cell division
- nucleosome assembly
Cellular Component
Where in the cell the gene product is active
- nucleus
- chromatin
Molecular Function
What the gene product does at the molecular level
- histone acetyltransferase regulator activity
- protein binding
- histone binding
- chromatin binding