Klhl2 Gene Summary [Mouse]
Predicted to enable actin binding activity; protein homodimerization activity; and ubiquitin-like ligase-substrate adaptor activity. Involved in protein ubiquitination. Located in cytoplasm. Part of Cul3-RING ubiquitin ligase complex. Is expressed in white fat. Orthologous to human KLHL2 (kelch like family member 2). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Klhl2 |
| Official Name | kelch-like 2, Mayven [Source:MGI Symbol;Acc:MGI:1924363] |
| Ensembl ID | ENSMUSG00000031605 |
| Bio databases IDs | |
| Aliases | kelch-like 2, Mayven |
| Synonyms | 6030411N21Rik, 8530402H02Rik, ABP-KELCH, kelch-like 2, Mayven, kelch-like family member 2, Klhl2 predicted, LOC100502725, MAV, MAYVEN, RGD1564686 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Klhl2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Kelch motif
- BTB_POZ
- protein binding activity, bridging
- protein binding
- BACK (BTB and C-terminal Kelch) domain
- identical protein binding
- Galactose oxidase, central domain
- BTB And C-terminal Kelch
- Broad-Complex, Tramtrack and Bric a brac
- actin binding
- protein homodimerization
- BTB/POZ domain
- Kelch domain
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- actin cytoskeleton
- cytosol
- actin stress fibers
- perikaryon
- lamellipodia
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Klhl2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- protein ubiquitination
Cellular Component
Where in the cell the gene product is active
- cytoplasm
- ruffle
- actin cytoskeleton
- cytosol
- Cul3-RING ubiquitin ligase complex
- lamellipodium
Molecular Function
What the gene product does at the molecular level
- identical protein binding
- protein binding
- actin binding