Mcts1 Gene Summary [Mouse]
Predicted to enable RNA cap binding activity; ribosomal small subunit binding activity; and translation factor activity, non-nucleic acid binding. Predicted to be involved in IRES-dependent viral translational initiation; cytoplasmic translational initiation; and ribosome disassembly. Predicted to be part of cytosolic small ribosomal subunit. Predicted to be active in cytoplasm. Is expressed in cerebral cortex ventricular layer; cortical plate; and embryo. Human ortholog(s) of this gene implicated in immunodeficiency 118. Orthologous to human MCTS1 (MCTS1 re-initiation and release factor). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Mcts1 |
| Official Name | malignant T cell amplified sequence 1 [Source:MGI Symbol;Acc:MGI:1916245] |
| Ensembl ID | ENSMUSG00000000355 |
| Bio databases IDs | |
| Aliases | malignant T cell amplified sequence 1 |
| Synonyms | 1500019M23RIK, IMD118, malignant T cell amplified sequence 1, MCT-1, MCTS1 re-initiation and release factor, MCTS1, re-initiation and release factor |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Mcts1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- PUA RNA binding domain
- arCOG04150 universal archaeal PUA-domain protein
- PUA domain
- eIF2D_N_like
- RNA cap binding
- translation initiation factor
- non-nucleic acid binding translation factor
- protein binding
- uncharacterized domain 2
- Pre-PUA-like domain
- translation regulator
- ribosomal small subunit binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- immunodeficiency type 118
- colon carcinoma
- colon epithelial cancer
role in cell
- growth
- apoptosis
- production in
- quantity
- invasion by
- transformation
- disassembly
- sphere formation by
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- ribosome
- cytosol
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Mcts1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- formation of translation preinitiation complex
- positive regulation of cell proliferation
- ribosome disassembly
- response to DNA damage stimulus
Cellular Component
Where in the cell the gene product is active
- cytosolic small ribosomal subunit
Molecular Function
What the gene product does at the molecular level
- translation initiation factor activity
- RNA binding
- protein binding