Cenpb Gene Summary [Mouse]
Predicted to enable DNA binding activity. Located in condensed chromosome, centromeric region and pericentric heterochromatin. Is expressed in several structures, including central nervous system and genitourinary system. Human ortholog(s) of this gene implicated in inner ear disease and primary biliary cholangitis. Orthologous to human CENPB (centromere protein B). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Cenpb |
| Official Name | centromere protein B [Source:MGI Symbol;Acc:MGI:88376] |
| Ensembl ID | ENSMUSG00000068267 |
| Bio databases IDs | |
| Aliases | centromere protein B |
| Synonyms | centromere protein B |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Cenpb often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- CENP-C binding domain
- DDE superfamily endonuclease
- Winged helix-turn-helix DNA-binding
- Tc5 transposase DNA-binding domain
- HTH_ARSR
- sequence-specific DNA binding
- HTH_CRP
- CENP-B N-terminal DNA-binding domain
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- oligozoospermia
- limited cutaneous systemic sclerosis
- hypoplasia
role in cell
- mitosis
- proliferation
- apoptosis
- cell cycle progression
- duplication
- morphology
- mass
- processing in
- cytokinesis
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- pericentrosomal region
- chromosome
- nucleoplasm
- nuclear bodies
- spindle pole
- nuclear scaffolds
- kinetochores
- centromeres
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Cenpb gene, providing context for its role in the cell.
Cellular Component
Where in the cell the gene product is active
- nucleus
- nuclear body
- condensed chromosome, centromeric region
- chromosome
- chromosome, centromeric region
- centromeric heterochromatin
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- DNA binding
- sequence-specific DNA binding
- chromatin binding
- centromeric DNA binding
- satellite DNA binding