Ube2d2a Gene Summary [Mouse]
Predicted to enable ubiquitin conjugating enzyme activity. Predicted to be involved in protein K48-linked ubiquitination; protein autoubiquitination; and ubiquitin-dependent protein catabolic process. Predicted to be part of ubiquitin ligase complex. Predicted to be active in nucleus. Orthologous to human UBE2D2 (ubiquitin conjugating enzyme E2 D2). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Ube2d2a |
| Official Name | ubiquitin-conjugating enzyme E2D 2A [Source:MGI Symbol;Acc:MGI:1930715] |
| Ensembl ID | ENSMUSG00000091896 |
| Bio databases IDs | |
| Aliases | ubiquitin-conjugating enzyme E2D 2A |
| Synonyms | 1500034D03Rik, 2E e2-17, E217kB, E2(17)KB2, PUBC1, Ubc2e, UBC4, UBC4/5, UBCH4, UBCH5B, Ube2d2a, ubiquitin-conjugating enzyme E2D 2, ubiquitin-conjugating enzyme E2D 2A |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Ube2d2a often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Ubiquitin-conjugating enzyme
- ubiquitin conjugating enzyme
- ubiquitin protein ligase activity
- ubiquitin-protein transferase activity
- UBCc_UEV
- enzyme
- protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- schizophrenia
- lung adenocarcinoma
- lung adenocarcinoma formation
- nonalcoholic fatty liver disease
role in cell
- ubiquitination in
- association in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- cytosol
- nucleoplasm
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Ube2d2a gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- protein modification process
- protein K48-linked ubiquitination
- protein polyubiquitination
- protein autoubiquitination
- ubiquitin-dependent protein catabolic process
- protein ubiquitination
Cellular Component
Where in the cell the gene product is active
- nucleus
- extracellular vesicular exosome
- ubiquitin ligase complex
- cytosol
- macromolecular complex
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- ubiquitin-protein ligase activity
- ATP binding
- protein binding
- ubiquitin protein ligase binding