Cblc Gene Summary [Mouse]
Predicted to enable several functions, including SH3 domain binding activity; phosphotyrosine residue binding activity; and signaling receptor binding activity. Acts upstream of or within several processes, including negative regulation of neuron apoptotic process; protein stabilization; and response to glial cell derived neurotrophic factor. Predicted to be part of ubiquitin ligase complex. Predicted to be active in membrane raft and plasma membrane. Is expressed in several structures, including alimentary system; brain; genitourinary system; lung; and sensory organ. Orthologous to human CBLC (Cbl proto-oncogene C). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Processed Transcript |
| Official Symbol | Cblc |
| Official Name | Casitas B-lineage lymphoma c [Source:MGI Symbol;Acc:MGI:1931457] |
| Ensembl ID | ENSMUSG00000040525 |
| Bio databases IDs | |
| Aliases | Casitas B-lineage lymphoma c |
| Synonyms | 2310076I21Rik, 2310079L19Rik, Casitas B-lineage lymphoma c, CBL-3, Cbl proto-oncogene C, CBL-SL, RNF57 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Cblc often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- CBL proto-oncogene N-terminal domain 1
- tyrosine kinase binding domain
- ubiquitin protein ligase activity
- epidermal growth factor receptor binding
- phosphotyrosine binding
- enzyme
- Ring finger domain
- protein binding
- proline rich domain
- SH3-domain binding
- zinc ion binding
- RING finger (Really Interesting New Gene) domain and U-box domain superfamily
- Ring finger
- Src homology 2 (SH2) domain
- CBL proto-oncogene N-terminus, EF hand-like domain
- CBL proto-oncogene N-terminus, SH2-like domain
- Zinc finger, C3HC4 type (RING finger)
- zinc-RING finger domain
Pathways
Biological processes and signaling networks where the Cblc gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- non-small cell lung cancer
- Crohn disease
- Alzheimer disease
- infection by Dengue virus 2
role in cell
- phosphorylation in
- apoptosis
- expression in
- growth
- cell death
- degradation in
- activation in
- upregulation in
- paclitaxel sensitivity
- ubiquitination in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Cblc gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of MAP kinase activity
- negative regulation of epidermal growth factor-activated receptor activity
- signal transduction
- cell surface receptor signaling pathway
- protein stabilization
- negative regulation of epidermal growth factor receptor signaling pathway
- protein ubiquitination
- negative regulation of neuron apoptotic process
- ubiquitin-dependent protein catabolic process
Cellular Component
Where in the cell the gene product is active
- membrane raft
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- phosphotyrosine binding
- zinc ion binding
- protein binding
- calcium ion binding
- epidermal growth factor receptor binding
- SH3 domain binding
- receptor tyrosine kinase binding