Pou3f2 Gene Summary [Mouse]
Enables DNA-binding transcription activator activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in neuron differentiation and regulation of gene expression. Acts upstream of or within several processes, including epidermis development; nervous system development; and regulation of axonogenesis. Located in nucleus. Part of transcription regulator complex. Is expressed in several structures, including future brain; genitourinary system; nervous system; sensory organ; and thymus. Orthologous to human POU3F2 (POU class 3 homeobox 2). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Pou3f2 |
| Official Name | POU domain, class 3, transcription factor 2 [Source:MGI Symbol;Acc:MGI:101895] |
| Ensembl ID | ENSMUSG00000095139 |
| Bio databases IDs | |
| Aliases | POU domain, class 3, transcription factor 2 |
| Synonyms | 9430075J19RIK, A230098E07RIK, Brain-2, BRN2, NOCT3, OCT7, OTF-7, POU class 3 homeobox 2, POU domain, class 3, transcription factor 2, POUF3 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Pou3f2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- RNA polymerase II transcription regulatory region sequence-specific binding transcriptional activator activity
- transcription regulator
- nucleic acid binding
- protein domain specific binding
- protein binding
- sequence-specific DNA binding
- identical protein binding
- DNA binding
- Pou domain - N-terminal to homeobox domain
- RNA polymerase II transcription factor activity, sequence-specific DNA binding
- double-stranded DNA binding
- homeodomain
- transcription factor activity
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- metastasis
- pervasive developmental disorder
- hepatic steatosis
- breast cancer
- schizophrenia
- bipolar disorder
- peeling of skin
- growth failure
- melanoma cancer
- hyperkeratosis
role in cell
- activation in
- expression in
- proliferation
- apoptosis
- differentiation
- transdifferentiation
- generation
- abnormal morphology
- migration
- specification
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- nuclear fraction
- nucleoplasm
- chromatin
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Pou3f2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- neuroendocrine cell differentiation
- neuron differentiation
- forebrain ventricular zone progenitor cell division
- hypothalamus cell differentiation
- positive regulation of cell proliferation
- epidermis development
- nervous system development
- neurohypophysis development
- forebrain astrocyte development
- cerebral cortex radially oriented cell migration
- neuron development
- positive regulation of transcription from RNA polymerase II promoter
- positive regulation of multicellular organism growth
- regulation of transcription from RNA polymerase II promoter
- negative regulation of gene expression
- myelination in peripheral nervous system
- neuron fate specification
- regulation of cell differentiation
- regulation of axonogenesis
- neuron fate commitment
Cellular Component
Where in the cell the gene product is active
- transcription factor complex
- chromatin
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- DNA binding
- identical protein binding
- sequence-specific DNA binding transcription factor activity
- protein binding
- RNA polymerase II core promoter proximal region sequence-specific DNA binding
- RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
- sequence-specific DNA binding RNA polymerase II transcription factor activity