Lhx8 Gene Summary [Mouse]
Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II transcription regulatory region sequence-specific DNA binding activity. Acts upstream of or within several processes, including female gonad development; forebrain neuron development; and odontogenesis of dentin-containing tooth. Located in female germ cell nucleus. Is expressed in several structures, including alimentary system; branchial arch; genitourinary system; nervous system; and respiratory system. Orthologous to human LHX8 (LIM homeobox 8). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Lhx8 |
| Official Name | LIM homeobox protein 8 [Source:MGI Symbol;Acc:MGI:1096343] |
| Ensembl ID | ENSMUSG00000096225 |
| Bio databases IDs | |
| Aliases | LIM homeobox protein 8 |
| Synonyms | L3, LHX7, LIM homeobox 8, LIM homeobox protein 8 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Lhx8 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- RNA polymerase II transcription factor activity, sequence-specific DNA binding
- transcription regulator
- LIM is a small protein-protein interaction domain, containing two zinc fingers
- double-stranded DNA binding
- protein binding
- sequence-specific DNA binding
- homeodomain
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- palatal shelves fail to meet at midline
- diverticulitis
- premature ovarian failure
- generalized anxiety disorder
role in cell
- quantity
- expression in
- number
- apoptosis
- development
- differentiation
- maturation
- degeneration
- lack
- abnormal morphology
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- chromatin
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Lhx8 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- neuron differentiation
- odontogenesis of dentin-containing tooth
- female gonad development
- forebrain neuron development
- regulation of transcription from RNA polymerase II promoter
- learning or memory
Cellular Component
Where in the cell the gene product is active
- female germ cell nucleus
- nucleus
- chromatin
Molecular Function
What the gene product does at the molecular level
- protein binding
- metal ion binding
- RNA polymerase II regulatory region sequence-specific DNA binding
- sequence-specific DNA binding RNA polymerase II transcription factor activity