Frmpd2 Gene Summary [Mouse]
Predicted to enable 1-phosphatidylinositol binding activity. Predicted to be involved in bicellular tight junction assembly. Predicted to be active in several cellular components, including apical part of cell; basolateral plasma membrane; and bicellular tight junction. Is expressed in central nervous system; ganglia; and retina. Orthologous to several human genes including FRMPD2 (FERM and PDZ domain containing 2). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Nonsense Mediated Decay |
| Official Symbol | Frmpd2 |
| Official Name | FERM and PDZ domain containing 2 [Source:MGI Symbol;Acc:MGI:2685472] |
| Ensembl ID | ENSMUSG00000108841 |
| Bio databases IDs | |
| Aliases | FERM and PDZ domain containing 2 |
| Synonyms | AABR07024637.1, FERM and PDZ domain containing 2, Gm1582, Gm626, LOC100910975, LOC108353074, PDZD5C, PDZK4, PDZK5C, Predicted gene 626, RGD1565652 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Frmpd2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Domain present in PSD-95, Dlg, and ZO-1/2
- FERM central domain
- Band 4.1 homologues
- canonical PDZ domain
- protein binding
- Pleckstrin homology-like domain
- PDZ domain
- phosphatidylinositol binding
- FERM N-terminal domain
- Protein Kinases, catalytic domain
- Ubl1_cv_Nsp3_N-like
- cpPDZ_Deg_HtrA-like
- FERM domain B-lobe
- FERM C-terminal PH-like domain
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- retinal hemorrhage
- non-insulin-dependent diabetes mellitus
- ovarian carcinoma
- epithelial ovarian cancer
- ophthalmic disorder
- Crohn disease
- fibromuscular dysplasia
- inflammatory bowel disease
- myopia
- refractive error
regulated by
- TP63
- ADCYAP1
role in cell
- assembly
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- basolateral membrane
- tight junctions
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Frmpd2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- tight junction assembly
Cellular Component
Where in the cell the gene product is active
- tight junction
- cytoskeleton
- apical part of cell
- cytoplasm
- basolateral plasma membrane
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- protein binding
- 1-phosphatidylinositol binding