Wwc1 Gene Summary [Mouse]
Predicted to enable kinase binding activity; signaling adaptor activity; and transcription coactivator activity. Predicted to be involved in several processes, including hippo signaling; negative regulation of organ growth; and regulation of intracellular signal transduction. Located in cytoplasm. Is expressed in cerebral cortex; female associated reproductive structure; forelimb bud ectoderm; primitive collecting duct; and retina. Orthologous to human WWC1 (WW and C2 domain containing 1). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Wwc1 |
| Official Name | WW, C2 and coiled-coil domain containing 1 [Source:MGI Symbol;Acc:MGI:2388637] |
| Ensembl ID | ENSMUSG00000018849 |
| Bio databases IDs | |
| Aliases | WW, C2 and coiled-coil domain containing 1 |
| Synonyms | AA408228, AU017197, HBEBP3, HBEBP36, KIAA0869, KIBRA, MEMRYQTL, PPP1R168, RGD1308329, WW and C2 domain containing 1, WW, C2 and coiled-coil domain containing 1 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Wwc1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- transcription regulator
- Domain with 2 conserved Trp (W) residues
- transcription co-activator
- kinase binding
- WW
- protein binding activity, bridging
- protein binding
- glutamic acid-rich domain
- WW domain
- C2 domain
Pathways
Biological processes and signaling networks where the Wwc1 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- cancer
- epithelial cancer
- abdominal cancer
- epithelial neoplasia
- digestive system cancer
- liver cancer
- liver neoplasia
- hepatocellular carcinoma
- adenoid cystic carcinoma
- acute myeloid leukemia
role in cell
- proliferation
- activation in
- phosphorylation in
- expression in
- invasion by
- apoptosis
- migration
- colony formation
- quantity
- colony formation by
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- organelle
- perinuclear region
- Nucleus
- cytosol
- membrane ruffles
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Wwc1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- regulation of hippo signaling cascade
- negative regulation of hippo signaling cascade
- negative regulation of cell proliferation
- regulation of transcription, DNA-dependent
- negative regulation of organ growth
- positive regulation of MAPK cascade
- negative regulation of transcription from RNA polymerase II promoter
- positive regulation of transcription, DNA-dependent
- establishment of cell polarity
- hippo signaling cascade
- regulation of intracellular transport
- cell migration
Cellular Component
Where in the cell the gene product is active
- nucleus
- perinuclear region of cytoplasm
- cytoplasm
- ruffle membrane
- cytosol
- macromolecular complex
Molecular Function
What the gene product does at the molecular level
- protein binding
- transcription coactivator activity
- signaling adaptor activity
- kinase binding
- binding, bridging