Ihh Gene Summary [Mouse]
Enables patched binding activity. Involved in several processes, including endochondral bone morphogenesis; heart looping; and regulation of T cell differentiation. Acts upstream of or within several processes, including camera-type eye development; skeletal system development; and tube morphogenesis. Located in extracellular matrix. Is expressed in several structures, including alimentary system; genitourinary system; limb; retina; and skeleton. Used to study Hirschsprung's disease; annular pancreas; and brachydactyly type A1. Human ortholog(s) of this gene implicated in acrocapitofemoral dysplasia; brachydactyly type A1; retinopathy of prematurity; and syndactyly type 1. Orthologous to human IHH (Indian hedgehog signaling molecule). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Ihh |
| Official Name | Indian hedgehog [Source:MGI Symbol;Acc:MGI:96533] |
| Ensembl ID | ENSMUSG00000006538 |
| Bio databases IDs | |
| Aliases | Indian hedgehog |
| Synonyms | BDA1, HHG-2, Indian hedgehog, Indian hedgehog signaling molecule |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Ihh often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Hedgehog amino-terminal signalling domain
- Hint (Hedgehog/Intein) domain N-terminal region
- Hint (Hedgehog/Intein) domain C-terminal region
- binding protein
- transferase
- Hint module
- Hint
- peptidase
- calcium ion binding
- enzyme
- protein binding
- patched binding
Pathways
Biological processes and signaling networks where the Ihh gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- cancer
- fibrosis
- epithelial neoplasia
- benign neoplasia
- papillomatosis
- diabetic nephropathy
- pemphigus foliaceus
- hypoplasia
- liver cancer
role in cell
- expression in
- apoptosis
- maturation
- proliferation
- differentiation
- formation
- quantity
- number
- upregulation in
- development
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Extracellular Space
- Plasma Membrane
- extracellular matrix
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Ihh gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- epithelial cell-cell adhesion
- somite development
- embryonic digestive tract morphogenesis
- head morphogenesis
- embryonic digit morphogenesis
- skeletal system development
- positive regulation of collagen biosynthetic process
- in utero embryonic development
- vitelline membrane formation
- bone resorption
- retinal pigment epithelium development
- heart looping
- cell fate specification
- positive regulation of epithelial cell proliferation
- embryonic pattern specification
- cell-cell signaling
- epithelial cell morphogenesis
- smoothened signaling pathway
- positive regulation of mesenchymal cell proliferation
- regulation of growth
- chondrocyte differentiation involved in endochondral bone morphogenesis
- embryonic skeletal joint development
- response to estradiol stimulus
- regulation of gene expression
- chondrocyte proliferation
- multicellular organism growth
- camera-type eye photoreceptor cell fate commitment
- negative regulation of T cell differentiation in thymus
- negative regulation of alpha-beta T cell differentiation
- positive regulation of T cell differentiation in thymus
- negative regulation of immature T cell proliferation in thymus
- positive regulation of transcription from RNA polymerase II promoter
- proteoglycan metabolic process
- positive regulation of alpha-beta T cell differentiation
- response to mechanical stimulus
- self proteolysis
- patterning of blood vessels
- osteoblast differentiation
- pancreas development
- maternal process involved in female pregnancy
- intein-mediated protein splicing
- smooth muscle tissue development
- cell maturation
- neuron development
- negative regulation of apoptotic process
- positive regulation of smoothened signaling pathway
- embryonic camera-type eye morphogenesis
- negative regulation of chondrocyte differentiation
- protein autoprocessing
- negative regulation of eye pigmentation
Cellular Component
Where in the cell the gene product is active
- endoplasmic reticulum membrane
- extracellular space
- Golgi membrane
- extracellular matrix
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- protein binding
- calcium ion binding
- peptidase activity
- patched binding