Vps4a Gene Summary [Mouse]
Predicted to enable ATP binding activity; ATP hydrolysis activity; and small GTPase binding activity. Involved in late endosomal microautophagy; multivesicular body assembly; and viral budding from plasma membrane. Acts upstream of or within endosome organization. Located in perinuclear region of cytoplasm. Is expressed in several structures, including alimentary system; branchial arch; central nervous system; genitourinary system; and nasal process. Orthologous to human VPS4A (vacuolar protein sorting 4 homolog A). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Vps4a |
| Official Name | vacuolar protein sorting 4A [Source:MGI Symbol;Acc:MGI:1890520] |
| Ensembl ID | ENSMUSG00000031913 |
| Bio databases IDs | |
| Aliases | vacuolar protein sorting 4A |
| Synonyms | 4930589C15Rik, CIMDAG, SKD1, SKD1A, SKD2, vacuolar protein sorting 4A, vacuolar protein sorting 4 homolog A, Vacuolar transport protein 4a, VPS4, VPS4-1 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Vps4a often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- MIT
- ATP-binding domain
- Vps4 C terminal oligomerization domain
- ATP binding
- enzyme binding
- MIT domain
- enzyme
- protein binding
- AAA+ lid domain
- ATPase
- Microtubule Interacting and Trafficking molecule domain
- MIT (microtubule interacting and transport) domain
- AAA domain (dynein-related subfamily)
- ATPase family associated with various cellular activities (AAA)
- binding protein
- ATPase domain
- active site
- P-loop containing Nucleoside Triphosphate Hydrolases
- ATPases associated with a variety of cellular activities
Pathways
Biological processes and signaling networks where the Vps4a gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- CIMDAG syndrome
- heart disease
- productive infection by HIV-1
role in cell
- quantity
- formation
- formation in
- accumulation in
- degradation in
- production in
- vacuolation
- reassembly
- abnormal morphology
- abscission
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- perinuclear region
- Nucleus
- vacuole
- Plasma Membrane
- endosomes
- centrosome
- lysosome
- contractile rings
- midbody
- Flemming body
- cytosol
- endosomal membrane
- spindle pole
- early endosomes
- late endosomes
- exosomes
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Vps4a gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- actomyosin contractile ring contraction
- vacuole organization
- protein targeting to lysosome
- cell division
- nuclear envelope organization
- vesicle-mediated transport
- non-lytic virus budding from plasma membrane
- autophagy
- endosomal transport
- negative regulation of cytokinesis
- intracellular cholesterol transport
- macroautophagy
- mitotic nuclear envelope reassembly
- membrane fission
- regulation of protein localization
- nucleus organization
- abscission
- membrane budding
- release of virus from host
- ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway
- plasma membrane repair
- multivesicular body sorting pathway
- endosomal vesicle fusion
- nuclear envelope reassembly
- mitotic metaphase plate congression
- vesicle uncoating
Cellular Component
Where in the cell the gene product is active
- spindle pole
- late endosome
- vacuolar membrane
- plasma membrane
- nuclear pore
- lysosome
- late endosome membrane
- nucleus
- early endosome
- centrosome
- extracellular vesicular exosome
- endosome
- perinuclear region of cytoplasm
- cytoplasm
- cytosol
- endosome membrane
- midbody
Molecular Function
What the gene product does at the molecular level
- ATPase activity
- ATP binding
- protein binding