Aga Gene Summary [Rat]
Enables N4-(beta-N-acetylglucosaminyl)-L-asparaginase activity and identical protein binding activity. Predicted to be involved in protein deglycosylation. Predicted to be located in endoplasmic reticulum and extracellular space. Predicted to be active in lysosome. Human ortholog(s) of this gene implicated in aspartylglucosaminuria and lysosomal storage disease. Orthologous to human AGA (aspartylglucosaminidase). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Aga |
| Official Name | aspartylglucosaminidase [Source:RGD Symbol;Acc:1309646] |
| Ensembl ID | ENSRNOG00000000108 |
| Bio databases IDs | |
| Aliases | aspartylglucosaminidase |
| Synonyms | AGU, aspartylglucosaminidase, ASRG, GA, L-ASPARAGINASE |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Aga often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- N4-(b-N-acetylglucosaminyl)-L-asparaginase
- L-Asparaginase type 2-like enzymes of the NTN-hydrolase superfamily
- enzyme
- protein binding
- identical protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- glycosylasparaginase deficiency
- aspartylglucosaminuria
- Finnish type aspartylglucosaminuria
- anuria
- neurodegeneration
- hereditary disorder
- ataxia
- hydronephrosis
- tubulo-interstitial fibrosis
- gliosis
role in cell
- apoptosis
- proliferation
- quantity
- degeneration
- cell survival
- vacuolation
- abnormal morphology
- transmembrane potential
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- azurophil granule lumen
- Extracellular Space
- lysosome
- Endoplasmic Reticulum
- neurites
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Aga gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- protein deglycosylation
- proteolysis
Cellular Component
Where in the cell the gene product is active
- extracellular space
- cytoplasm
- endoplasmic reticulum
- extracellular region
- azurophil granule lumen
- lysosome
Molecular Function
What the gene product does at the molecular level
- protein binding
- N4-(beta-N-acetylglucosaminyl)-L-asparaginase activity
- peptidase activity