Grm6 Gene Summary [Rat]
Enables adenylate cyclase inhibiting G protein-coupled glutamate receptor activity. Involved in adenylate cyclase-inhibiting G protein-coupled glutamate receptor signaling pathway and chemical synaptic transmission. Predicted to be located in Golgi membrane; endoplasmic reticulum membrane; and new growing cell tip. Predicted to be active in cell tip; dendrite; and plasma membrane. Human ortholog(s) of this gene implicated in congenital stationary night blindness 1B. Orthologous to human GRM6 (glutamate metabotropic receptor 6). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Grm6 |
| Official Name | glutamate metabotropic receptor 6 [Source:RGD Symbol;Acc:2747] |
| Ensembl ID | ENSRNOG00000000233 |
| Bio databases IDs | |
| Aliases | glutamate metabotropic receptor 6 |
| Synonyms | BC021919, CSNB1B, glutamate metabotropic receptor 6, glutamate receptor, metabotropic 6, Gm3, GPRC1F, mGlu6, MGLUR6, nerg1, nob2, nob3, nob4 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Grm6 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- G-protein coupled receptor
- Receptor family ligand binding region
- G beta gamma protein binding domain
- protein binding
- 7 transmembrane sweet-taste receptor of 3 GCPR
- seven-transmembrane G protein-coupled receptor superfamily
- glutamate receptor
- adenylate cyclase inhibiting metabotropic glutamate receptor
- Type 1 periplasmic binding fold superfamily
- transmembrane domain
- Nine Cysteines Domain of family 3 GPCR
- protein homodimerization
- group III metabotropic glutamate receptor
Pathways
Biological processes and signaling networks where the Grm6 gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- cancer
- congenital stationary night blindness type 1B
- retinal dystrophy
- congenital stationary night blindness
- early-onset high myopia
- Leber congenital amaurosis type 1
- congenital stationary night blindness type 1C
- GRM6-related retinopathy
- night blindness
- systemic lupus erythematosus
role in cell
- activation in
- production in
- morphology
- assembly
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- dendrite tip
- postsynaptic invagination
- postsynaptic region
- cellular membrane
- endoplasmic reticulum membrane
- postsynaptic membrane
- Golgi membrane
- cell tip
- dendrites
- ribbon synapse
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Grm6 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- detection of light stimulus involved in visual perception
- locomotory behavior
- retina development in camera-type eye
- detection of visible light
- adenylate cyclase-inhibiting G-protein coupled glutamate receptor signaling pathway
- synaptic transmission
- G-protein coupled glutamate receptor signaling pathway
- regulation of synaptic transmission, glutamatergic
Cellular Component
Where in the cell the gene product is active
- endoplasmic reticulum membrane
- dendrite
- Golgi membrane
- synapse
- new growing cell tip
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- G-protein coupled receptor activity
- protein homodimerization activity
- protein binding
- glutamate receptor activity
- adenylate cyclase inhibiting G-protein coupled glutamate receptor activity