Grm6 Gene Summary [Mouse]
Predicted to enable adenylate cyclase inhibiting G protein-coupled glutamate receptor activity and protein homodimerization activity. Involved in locomotory behavior and sensory perception of light stimulus. Acts upstream of or within several processes, including retina development in camera-type eye; signal transduction; and synapse assembly. Located in new growing cell tip. Is active in cell tip and dendrite. Is expressed in prostate gland; retina inner nuclear layer; and testis. Used to study congenital stationary night blindness 1B. Human ortholog(s) of this gene implicated in congenital stationary night blindness 1B. Orthologous to human GRM6 (glutamate metabotropic receptor 6). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Processed Transcript |
| Official Symbol | Grm6 |
| Official Name | glutamate receptor, metabotropic 6 [Source:MGI Symbol;Acc:MGI:1351343] |
| Ensembl ID | ENSMUSG00000000617 |
| Bio databases IDs | |
| Aliases | glutamate receptor, metabotropic 6 |
| Synonyms | BC021919, CSNB1B, glutamate metabotropic receptor 6, glutamate receptor, metabotropic 6, Gm3, GPRC1F, mGlu6, MGLUR6, nerg1, nob2, nob3, nob4 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Grm6 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- G-protein coupled receptor
- Receptor family ligand binding region
- G beta gamma protein binding domain
- protein binding
- 7 transmembrane sweet-taste receptor of 3 GCPR
- seven-transmembrane G protein-coupled receptor superfamily
- glutamate receptor
- adenylate cyclase inhibiting metabotropic glutamate receptor
- Type 1 periplasmic binding fold superfamily
- transmembrane domain
- Nine Cysteines Domain of family 3 GPCR
- protein homodimerization
- group III metabotropic glutamate receptor
Pathways
Biological processes and signaling networks where the Grm6 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
- Breast Cancer Regulation by Stathmin1
- cAMP-mediated signaling
- Cellular Effects of Sildenafil (Viagra)
- CREB Signaling in Neurons
- G-Protein Coupled Receptor Signaling
- Glutamate Receptor Signaling
- Gαi Signaling
- Neuropathic Pain Signaling In Dorsal Horn Neurons
- Phagosome Formation
- Synaptic Long Term Depression
- Synaptic Long Term Potentiation
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- cancer
- congenital stationary night blindness type 1B
- retinal dystrophy
- congenital stationary night blindness
- early-onset high myopia
- Leber congenital amaurosis type 1
- congenital stationary night blindness type 1C
- GRM6-related retinopathy
- night blindness
- systemic lupus erythematosus
role in cell
- activation in
- production in
- morphology
- assembly
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- dendrite tip
- postsynaptic invagination
- postsynaptic region
- cellular membrane
- endoplasmic reticulum membrane
- postsynaptic membrane
- Golgi membrane
- cell tip
- dendrites
- ribbon synapse
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Grm6 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- detection of light stimulus involved in visual perception
- locomotory behavior
- retina development in camera-type eye
- detection of visible light
- adenylate cyclase-inhibiting G-protein coupled glutamate receptor signaling pathway
- synaptic transmission
- G-protein coupled glutamate receptor signaling pathway
- regulation of synaptic transmission, glutamatergic
Cellular Component
Where in the cell the gene product is active
- endoplasmic reticulum membrane
- dendrite
- Golgi membrane
- synapse
- new growing cell tip
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- G-protein coupled receptor activity
- protein homodimerization activity
- protein binding
- glutamate receptor activity
- adenylate cyclase inhibiting G-protein coupled glutamate receptor activity