Mst1r Gene Summary [Rat]
Predicted to enable enzyme binding activity and transmembrane receptor protein tyrosine kinase activity. Predicted to be involved in several processes, including cell surface receptor protein tyrosine kinase signaling pathway; phagocytosis; and positive regulation of intracellular signal transduction. Predicted to act upstream of or within response to virus. Predicted to be located in stress fiber and vacuole. Predicted to be part of receptor complex. Predicted to be active in plasma membrane. Human ortholog(s) of this gene implicated in nasopharynx carcinoma. Orthologous to human MST1R (macrophage stimulating 1 receptor). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Mst1r |
| Official Name | macrophage stimulating 1 receptor [Source:RGD Symbol;Acc:1306465] |
| Ensembl ID | ENSRNOG00000032618 |
| Bio databases IDs | |
| Aliases | macrophage stimulating 1 receptor |
| Synonyms | CD136, CDw136, Fv-2, macrophage stimulating 1 receptor, macrophage stimulating 1 receptor (c-met-related tyrosine kinase), MSPR, NPCA3, p185-Ron, PTK8, RON, SEA, STK |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Mst1r often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Plexin repeat
- ATP-binding domain
- protein-tyrosine kinase
- Protein kinase domain
- Grb2 binding domain
- semaphorin domain
- intracellular domain
- tail domain
- Sema domain
- Tyrosine kinase, catalytic domain
- transmembrane receptor
- extracellular domain
- Protein kinase (unclassified specificity)
- Protein tyrosine and serine/threonine kinase
- IPT
- enzyme binding
- protein binding
- kinase
- Serine/Threonine protein kinases, catalytic domain
- macrophage colony stimulating factor receptor
- kinase domain
- Protein Kinases, catalytic domain
- transmembrane domain
- IPT/TIG domain
- tyrosine kinase domain
- The Sema domain, a protein interacting module, of semaphorins and plexins
Pathways
Biological processes and signaling networks where the Mst1r gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- non-squamous lung carcinoma
- stage IV lung squamous cell carcinoma
- metastasis
- epithelial neoplasia
- epithelial cancer
- cancer
- breast cancer
- locally advanced non-small cell lung cancer
- prostate cancer
role in cell
- expression in
- apoptosis
- survival
- colony formation
- activation in
- phosphorylation in
- formation
- production in
- proliferation
- activation
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- Cytoplasm
- cell surface
- cellular membrane
- vacuole
- granules
- actin stress fibers
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Mst1r gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- positive regulation of MAP kinase activity
- multicellular organismal development
- signal transduction
- macrophage colony-stimulating factor signaling pathway
- positive regulation of cell proliferation
- nervous system development
- transmembrane receptor protein tyrosine kinase signaling pathway
- response to virus
- defense response
- single fertilization
- innate immune response
- phagocytosis
- positive regulation of kinase activity
- cell migration
- positive regulation of protein kinase B signaling cascade
Cellular Component
Where in the cell the gene product is active
- stress fiber
- receptor complex
- vacuole
- plasma membrane
- cell surface
Molecular Function
What the gene product does at the molecular level
- ATP binding
- protein binding
- transmembrane receptor protein tyrosine kinase activity
- macrophage colony-stimulating factor receptor activity
- enzyme binding