Septin8 Gene Summary [Rat]
Enables SNARE binding activity. Involved in regulation of SNARE complex assembly. Located in myelin sheath. Is active in presynapse. Orthologous to human SEPTIN8 (septin 8). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Septin8 |
| Official Name | septin 8 [Source:RGD Symbol;Acc:1308449] |
| Ensembl ID | ENSRNOG00000007462 |
| Bio databases IDs | |
| Aliases | septin 8 |
| Synonyms | KIAA0202, SEP2, SEPT8 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Septin8 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- SNARE binding
- protein binding
- zDHHC ankyrin repeat binding domain
- Septin
- P-loop containing Nucleoside Triphosphate Hydrolases
Pathways
Biological processes and signaling networks where the Septin8 gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Extracellular Space
- myelin enriched fraction
- presynaptic regions
- myelin sheath
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Septin8 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- regulation of SNARE complex assembly
- protein localization
Cellular Component
Where in the cell the gene product is active
- microtubule cytoskeleton
- cell division site
- synaptic vesicle membrane
- septin complex
- axon
- septin ring
Molecular Function
What the gene product does at the molecular level
- GTP binding
- protein binding
- GTPase activity
- binding, bridging