Anks1a Gene Summary [Rat]
Predicted to enable ephrin receptor binding activity. Predicted to be involved in ephrin receptor signaling pathway; neuron remodeling; and substrate-dependent cell migration. Predicted to act upstream of or within negative regulation of ubiquitin-dependent protein catabolic process and regulation of ephrin receptor signaling pathway. Predicted to be located in neuron projection and nucleoplasm. Predicted to be active in cytosol. Orthologous to human ANKS1A (ankyrin repeat and sterile alpha motif domain containing 1A). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Anks1a |
| Official Name | ankyrin repeat and sterile alpha motif domain containing 1A [Source:RGD Symbol;Acc:1309183] |
| Ensembl ID | ENSRNOG00000000498 |
| Bio databases IDs | |
| Aliases | ankyrin repeat and sterile alpha motif domain containing 1A |
| Synonyms | ANKS1, ankyrin repeat and SAM domain containing 1, ankyrin repeat and sterile alpha motif domain containing 1A, ankyrin repeat and sterile α motif domain containing 1A, KIAA0229, LOC224650, mKIAA0229, ODIN |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Anks1a often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Sterile alpha motif
- Ankyrin repeats (many copies)
- SAM (Sterile alpha motif )
- SAM domain
- SAM domain (Sterile alpha motif)
- Ankyrin repeats (3 copies)
- ephrin receptor binding
- protein binding
- phosphotyrosine binding domain
- Pleckstrin homology-like domain
- Ankyrin repeat
- ankyrin repeats
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- systemic lupus erythematosus
- coronary artery disease
- cognitive impairment
- beta amyloidosis
- systemic sclerosis
- alcoholism
- non-small cell lung cancer
- psoriasis
- non-small cell lung carcinoma
- metabolic syndrome X
role in cell
- expression in
- migration
- degradation in
- mitogenesis
- remodeling
- retraction
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- cytosol
- nucleoplasm
- neurites
- nerve ending
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Anks1a gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- ephrin receptor signaling pathway
- substrate-dependent cell migration
- neuron remodeling
Cellular Component
Where in the cell the gene product is active
- cytosol
- neuron projection
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- protein binding
- ephrin receptor binding