Med24 Gene Summary [Rat]
Enables histone acetyltransferase activity and transcription coactivator activity. Contributes to ubiquitin protein ligase activity. Involved in protein ubiquitination. Part of ubiquitin ligase complex. Orthologous to human MED24 (mediator complex subunit 24). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Med24 |
| Official Name | mediator complex subunit 24 [Source:RGD Symbol;Acc:1564565] |
| Ensembl ID | ENSRNOG00000008711 |
| Bio databases IDs | |
| Aliases | mediator complex subunit 24 |
| Synonyms | 911GSE, ARC100, CRSP100, CRSP4, D11Ertd307e, DRIP100, GSE2, Med100, MED5, mediator complex subunit 24, Pparb2, Pparbp2, THRAP4, TRAP100 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Med24 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- transcription regulator
- histone acetyltransferase
- transcription co-activator
- binding protein
- ubiquitin protein ligase activity
- transcription cofactor
- Mediator complex subunit 24 N-terminal
- protein binding
- thyroid hormone receptor binding
Pathways
Biological processes and signaling networks where the Med24 gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- major depression
- plasma cell myeloma
- neuroticism
- asthma
- cardiovascular disorder
- pancreatic carcinoma
- pancreatic epithelial cancer
- neurotic disorder
- neutropenia
- leukopenia
role in cell
- survival
- cell viability
- olaparib resistance
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- interchromatin granule cluster fractions
- nuclear fraction
- nucleoplasm
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Med24 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- positive regulation of transcription elongation from RNA polymerase II promoter
- RNA polymerase II transcriptional preinitiation complex assembly
- positive regulation of transcription initiation from RNA polymerase II promoter
- positive regulation of transcription, DNA-dependent
Cellular Component
Where in the cell the gene product is active
- nucleus
- core mediator complex
- mediator complex
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- protein binding
- transcription cofactor activity
- transcription coactivator activity
- ligand-dependent nuclear receptor transcription coactivator activity
- vitamin D receptor binding
- thyroid hormone receptor binding