Hpd Gene Summary [Rat]
Enables 4-hydroxyphenylpyruvate dioxygenase activity; iron ion binding activity; and protein homodimerization activity. Involved in tyrosine catabolic process. Located in Golgi membrane and endoplasmic reticulum membrane. Human ortholog(s) of this gene implicated in hawkinsinuria and tyrosinemia type III. Orthologous to human HPD (4-hydroxyphenylpyruvate dioxygenase). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Hpd |
| Official Name | 4-hydroxyphenylpyruvate dioxygenase [Source:RGD Symbol;Acc:61974] |
| Ensembl ID | ENSRNOG00000001338 |
| Bio databases IDs | |
| Aliases | 4-hydroxyphenylpyruvate dioxygenase |
| Synonyms | 4-HPPD, 4-hydroxyphenylpyruvate dioxygenase, 4-hydroxyphenylpyruvic acid dioxygenase, FLA, Flp, GLOD3, HPPD, HPPDASE, Laf, PPD |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Hpd often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- glyoxalase I/type I extradiol dioxygenase/antibiotic resistance protein metal-binding domain
- protein homodimerization
- 4-hydroxyphenylpyruvate dioxygenase
- iron ion binding
- enzyme
- protein binding
- Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- epithelial cancer
- neoplasia
- tyrosinemia type I
- hepatocellular carcinoma
- alkaptonuria
- hepatitis B virus-related hepatocellular carcinoma
- liver cancer
- hawkinsinuria
- type III tyrosinemia
- cholangiocarcinoma
role in cell
- expression in
- proliferative capacity
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- cellular membrane
- Golgi Apparatus
- Endoplasmic Reticulum
- cytosol
- endoplasmic reticulum membrane
- Golgi membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Hpd gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- L-phenylalanine catabolic process
- tyrosine catabolic process
Cellular Component
Where in the cell the gene product is active
- endoplasmic reticulum membrane
- extracellular vesicular exosome
- cytosol
- Golgi membrane
Molecular Function
What the gene product does at the molecular level
- protein homodimerization activity
- metal ion binding
- 4-hydroxyphenylpyruvate dioxygenase activity