Oxt Gene Summary [Rat]
Enables neuropeptide hormone activity and oxytocin receptor binding activity. Involved in several processes, including positive regulation of secretion by cell; positive regulation of smooth muscle contraction; and regulation of blood pressure. Located in extracellular space; secretory granule; and terminal bouton. Is active in neuronal dense core vesicle. Used to study gastric ulcer and hypertension. Biomarker of amphetamine abuse and hypertension. Orthologous to human OXT (oxytocin/neurophysin I prepropeptide). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Oxt |
| Official Name | oxytocin/neurophysin I prepropeptide [Source:RGD Symbol;Acc:3238] |
| Ensembl ID | ENSRNOG00000021225 |
| Bio databases IDs | |
| Aliases | oxytocin/neurophysin I prepropeptide |
| Synonyms | OP, OT, OT-NPI, OXT-NPI, Oxy, Oxytocin, Oxytocin-neurophysin i, oxytocin/neurophysin I prepropeptide, Prepro-oxytocin |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Oxt often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Neurohypophysial hormones, C-terminal Domain
- G-protein-coupled receptor binding
- protein binding
- neuropeptide hormone
Pathways
Biological processes and signaling networks where the Oxt gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- schizophrenia
- polycystic ovary syndrome
- anxiety disorder
- social anxiety disorder
- pain
- postoperative pain
- alcoholism
- post-traumatic stress disorder
- cocaine dependence
- schizoaffective disorder
role in cell
- expression in
- cell death
- inhibition
- growth
- binding
- accumulation in
- phosphorylation in
- production in
- activation
- binding in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Extracellular Space
- membrane fraction
- Cytoplasm
- vesicles
- granules
- secretory granules
- perikaryon
- axon terminals
- plasma
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Oxt gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- drinking behavior
- response to food
- sperm ejaculation
- positive regulation of female receptivity
- response to prostaglandin E stimulus
- response to progesterone stimulus
- response to cAMP
- positive regulation of penile erection
- memory
- maternal behavior
- eating behavior
- positive regulation of prostaglandin secretion
- heart development
- response to retinoic acid
- grooming behavior
- response to ether
- response to glucocorticoid stimulus
- negative regulation of urine volume
- positive regulation of synapse assembly
- response to electrical stimulus
- social behavior
- male mating behavior
- signal transduction
- positive regulation of synaptic transmission
- positive regulation of hindgut contraction
- response to cocaine
- negative regulation of blood pressure
- female pregnancy
- response to peptide hormone stimulus
- positive regulation of blood pressure
- response to sucrose stimulus
- elevation of cytosolic calcium ion concentration
- positive regulation of ossification
- maternal aggressive behavior
- regulation of heart rate
- response to amphetamine
- positive regulation of uterine smooth muscle contraction
- response to estradiol stimulus
- positive regulation of norepinephrine secretion
- response to activity
Cellular Component
Where in the cell the gene product is active
- extracellular space
- terminal button
- secretory granule
- extracellular region
Molecular Function
What the gene product does at the molecular level
- oxytocin receptor binding
- protein binding
- neurohypophyseal hormone activity
- neuropeptide hormone activity
- V1A vasopressin receptor binding