Gpc2 Gene Summary [Rat]
Involved in neuron differentiation; positive regulation of neuron projection development; and smoothened signaling pathway. Predicted to be located in endoplasmic reticulum. Predicted to be active in cell surface and synapse. Orthologous to human GPC2 (glypican 2). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Gpc2 |
| Official Name | glypican 2 [Source:RGD Symbol;Acc:621363] |
| Ensembl ID | ENSRNOG00000001367 |
| Bio databases IDs | |
| Aliases | glypican 2 |
| Synonyms | 2410016G05Rik, Cerebroglycan, glypican 2, glypican 2 cerebroglycan |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Gpc2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Glypican
- protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- soft tissue sarcoma cancer
- neuroblastoma
- prostate cancer
- neuroblastoma formation
- epithelial cancer
- organismal death
- rectal adenocarcinoma
- colorectal carcinomagenesis
- rectum cancer
- hereditary paraganglioma-pheochromocytoma syndrome
role in cell
- expression in
- growth
- differentiation
- development
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- Golgi lumen
- cell surface
- cellular membrane
- Endoplasmic Reticulum
- lysosomal compartment
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Gpc2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- neuron differentiation
- smoothened signaling pathway
- positive regulation of neuron projection development
- regulation of signal transduction
- cell migration
Cellular Component
Where in the cell the gene product is active
- endoplasmic reticulum
- lysosomal lumen
- synapse
- extracellular region
- Golgi lumen
- plasma membrane
- cell surface
Molecular Function
What the gene product does at the molecular level
- protein binding