Actl6b Gene Summary [Rat]
Predicted to enable chromatin binding activity. Involved in spinal cord development. Located in nucleus. Human ortholog(s) of this gene implicated in developmental and epileptic encephalopathy 76. Orthologous to human ACTL6B (actin like 6B). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Actl6b |
| Official Name | actin-like 6B [Source:RGD Symbol;Acc:1307763] |
| Ensembl ID | ENSRNOG00000001408 |
| Bio databases IDs | |
| Aliases | actin-like 6B |
| Synonyms | actin-like 6B, ACTL6, ArpNa, arpNalpha, BAF53B, DEE76, EIEE76, IDDSSAD, SMARCN2 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Actl6b often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- structural constituent of cytoskeleton
- Actin
- protein binding
- ASKHA_ATPase-like
Pathways
Biological processes and signaling networks where the Actl6b gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- intellectual developmental disorder with severe speech and ambulation defects
- early infantile epileptic encephalopathy type 76
- schizophrenia
- pervasive developmental disorder
- major depression
- hereditary disorder
- epilepsy
- mental retardation
- hyperactive behavior
role in cell
- formation
- G2/M phase
- development
- remodeling
- maturation
- abnormal morphology
- replication in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- nuclear fraction
- plasma
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Actl6b gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- regulation of mitotic metaphase/anaphase transition
- cytoskeleton organization
- positive regulation of cell proliferation
- nervous system development
- neuron maturation
- positive regulation of cell differentiation
- positive regulation of myoblast differentiation
- chromatin organization
- regulation of nucleotide-excision repair
- regulation of transcription from RNA polymerase II promoter
- chromatin remodeling
- negative regulation of cell differentiation
- positive regulation of transcription, DNA-dependent
- positive regulation of T cell differentiation
- regulation of G1/S transition of mitotic cell cycle
- positive regulation of double-strand break repair
- regulation of G0 to G1 transition
- dendrite development
Cellular Component
Where in the cell the gene product is active
- SWI/SNF complex
- nucleus
- NuA4 histone acetyltransferase complex
- nuclear matrix
- brahma complex
- nBAF complex
- kinetochore
- RSC complex
- chromatin
Molecular Function
What the gene product does at the molecular level
- transcription coactivator activity
- structural constituent of cytoskeleton
- chromatin binding