Cr1l Gene Summary [Rat]
This gene encodes a membrane-bound inhibitor of complement activation, which contains several tandemly arranged short consensus repeats (SCRs) of approximately 60 amino acids. The encoded protein may play a role in tumor immune surveillance, which is unrelated to complement inhibition. Three alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Details
| Type | Protein Coding |
| Official Symbol | Cr1l |
| Official Name | complement C3b/C4b receptor 1 like [Source:RGD Symbol;Acc:2399] |
| Ensembl ID | ENSRNOG00000008193 |
| Bio databases IDs | |
| Aliases | complement C3b/C4b receptor 1 like |
| Synonyms | complement C3b/C4b receptor 1 like, Cr1, CRRY, LOC100911729, Mcp, mCRY |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Cr1l often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- CCP
- extracellular domain
- complement receptor
- cytoplasmic domain
- protein binding
- Sushi repeat (SCR repeat)
- complement component C3b receptor
- transmembrane receptor
- SUSHI repeat
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- multiple sclerosis
- T-cell lymphopenia
- Alzheimer disease
- dextran sodium sulfate-induced colitis
- cleft lip
- gastroesophageal reflux
- shock response
- reperfusion injury
- glomerulosclerosis
- renal failure
role in cell
- phosphorylation in
- proliferation
- production in
- activation in
- apoptosis
- activation
- differentiation
- survival
- function
- clustering
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- cytoskeleton
- cell surface
- basolateral cell surfaces
- plasma membrane extracellular face
- basolateral membrane
- basal membrane
- membrane rafts
- brush border
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Cr1l gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of complement activation, classical pathway
- T cell mediated immunity
- regulation of complement activation
Cellular Component
Where in the cell the gene product is active
- extracellular space
- cytoplasm
- receptor complex
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- protein binding