Ctsk Gene Summary [Rat]
Predicted to enable several functions, including collagen binding activity; cysteine-type endopeptidase activity; and fibronectin binding activity. Involved in several processes, including bone resorption; cellular response to transforming growth factor beta stimulus; and cellular response to zinc ion starvation. Located in extracellular space. Biomarker of intracranial aneurysm and otitis media. Human ortholog(s) of this gene implicated in pycnodysostosis. Orthologous to human CTSK (cathepsin K). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Ctsk |
| Official Name | cathepsin K [Source:RGD Symbol;Acc:61810] |
| Ensembl ID | ENSRNOG00000021155 |
| Bio databases IDs | |
| Aliases | cathepsin K |
| Synonyms | Cathepsin K, catK, CTS02, CTSO, CTSO1, CTSO2, MMS10-Q, Ms10q, PKND, PYCD |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Ctsk often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- cathepsin K
- cysteine-type peptidase
- cysteine endopeptidase
- Cathepsin propeptide inhibitor domain (I29)
- serine endopeptidase
- binding protein
- peptidase
- Peptidase_C1
- collagen binding
- protein binding
- fibronectin binding
Pathways
Biological processes and signaling networks where the Ctsk gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- non-insulin-dependent diabetes mellitus
- postmenopausal osteoporosis
- osteoporosis
- diabetes mellitus
- epithelial cancer
- neoplasia
- pyknodysostosis
- osteolytic bone disease
- plasma cell myeloma
- lung cancer
role in cell
- proliferation
- apoptosis
- expression in
- number
- migration
- signaling in
- formation
- invasion
- disassembly
- colony formation ability
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- intracellular membrane-bounded organelle
- Extracellular Space
- perinuclear region
- endosomes
- vesicles
- lysosome
- cytoplasmic face of plasma membrane
- plasma membrane extracellular face
- plasma membrane projections
- lysosomal compartment
- nucleoplasm
- zymogen granules
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Ctsk gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of cartilage development
- thyroid hormone generation
- extracellular matrix disassembly
- response to organic cyclic compound
- macromitophagy
- response to ethanol
- cellular response to transforming growth factor beta stimulus
- response to insulin stimulus
- immune response
- bone resorption
- apoptotic process
- proteolysis
- intramembranous ossification
- positive regulation of peptidase activity
- cellular response to tumor necrosis factor
- collagen catabolic process
- cellular response to zinc ion starvation
- proteolysis involved in cellular protein catabolic process
- positive regulation of apoptotic signaling pathway
Cellular Component
Where in the cell the gene product is active
- extracellular space
- intracellular membrane-bounded organelle
- endolysosome lumen
- external side of plasma membrane
- lysosomal lumen
- extracellular region
- apical plasma membrane
- nucleoplasm
- lysosome
Molecular Function
What the gene product does at the molecular level
- protein binding
- proteoglycan binding
- collagen binding
- serine-type endopeptidase activity
- fibronectin binding
- cysteine-type endopeptidase activity
- cysteine-type peptidase activity
- cysteine-type endopeptidase activator activity involved in apoptotic process