Mief1 Gene Summary [Rat]
Predicted to enable identical protein binding activity; mitochondrial large ribosomal subunit binding activity; and purine ribonucleotide binding activity. Involved in cellular response to hypoxia. Predicted to be located in mitochondrial matrix. Predicted to be active in mitochondrial outer membrane. Human ortholog(s) of this gene implicated in optic atrophy. Orthologous to human MIEF1 (mitochondrial elongation factor 1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Mief1 |
| Official Name | mitochondrial elongation factor 1 [Source:RGD Symbol;Acc:1359173] |
| Ensembl ID | ENSRNOG00000017553 |
| Bio databases IDs | |
| Aliases | mitochondrial elongation factor 1 |
| Synonyms | A230016E22, AI452372, AL022312.1, AltMIEF1, D3A, dJ1104E15.3, FLJ20232, HSU79252, L0R8F8, MID51, MIEF1-MP, mitochondrial elongation factor 1, OPA14, SMCR7L |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Mief1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Mab-21 protein HhH/H2TH-like domain
- GDP binding
- ADP binding
- ribosome binding
- Mab-21 protein nucleotidyltransferase domain
- protein binding
- identical protein binding
- ribosomal large subunit binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Mitochondria
- mitochondrial matrix
- mitochondrial outer membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Mief1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- positive regulation of protein targeting to membrane
- positive regulation of mitochondrial fusion
- mitochondrial fusion
- cellular response to hypoxia
- positive regulation of mitochondrial fission
- mitochondrial fission
Cellular Component
Where in the cell the gene product is active
- peroxisome
- mitochondrion
- mitochondrial outer membrane
Molecular Function
What the gene product does at the molecular level
- identical protein binding
- protein binding
- GDP binding
- ADP binding