Cldn14 Gene Summary [Rat]
Predicted to enable structural molecule activity. Predicted to be involved in bicellular tight junction assembly and cell adhesion. Predicted to be active in bicellular tight junction and plasma membrane. Human ortholog(s) of this gene implicated in autosomal recessive nonsyndromic deafness 29. Orthologous to human CLDN14 (claudin 14). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Cldn14 |
| Official Name | claudin 14 [Source:RGD Symbol;Acc:1309165] |
| Ensembl ID | ENSRNOG00000001691 |
| Bio databases IDs | |
| Aliases | claudin 14 |
| Synonyms | claudin 14, DFNB29 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Cldn14 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- PMP-22/EMP/MP20/Claudin family
- extracellular loop
- protein binding
- identical protein binding
Pathways
Biological processes and signaling networks where the Cldn14 gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- androgenic alopecia
- autosomal recessive deafness type 29
- autosomal recessive deafness
- colon adenocarcinoma
- colon epithelial cancer
- gonadal dysgenesis with auditory dysfunction, autosomal recessive inheritance
- familial nonsyndromic hearing impairment
- sensorineural hearing loss
regulates
- Ca2+
- protein-protein complex
role in cell
- morphology
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- cellular membrane
- tight junctions
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Cldn14 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- calcium-independent cell-cell adhesion
- macromolecular complex assembly
- tight junction assembly
- cell adhesion
Cellular Component
Where in the cell the gene product is active
- tight junction
- endoplasmic reticulum
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- identical protein binding
- protein binding
- structural molecule activity