Cldn16 Gene Summary [Rat]
Predicted to enable PDZ domain binding activity; identical protein binding activity; and paracellular tight junction channel activity. Involved in paracellular transport; positive regulation of calcium ion transport; and transepithelial transport. Located in bicellular tight junction. Used to study hypertension. Human ortholog(s) of this gene implicated in renal hypomagnesemia 3 and renal tubular transport disease. Orthologous to human CLDN16 (claudin 16). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Cldn16 |
| Official Name | claudin 16 [Source:RGD Symbol;Acc:620322] |
| Ensembl ID | ENSRNOG00000055138 |
| Bio databases IDs | |
| Aliases | claudin 16 |
| Synonyms | claudin-16, HOMG3, LOC107986170, PCLN1, PLCN-1 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Cldn16 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- cytoplasmic domain
- PMP-22/EMP/MP20/Claudin family
- extracellular loop
- protein binding
- magnesium ion transporter
- identical protein binding
- transporter
- PDZ-domain binding
Pathways
Biological processes and signaling networks where the Cldn16 gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- colorectal cancer
- renal hypomagnesemia type 3
- self-limiting childhood hypercalciuria
- gestational diabetes mellitus
- nephrocalcinosis
- NISCH syndrome
- diabetic nephropathy
- hypercalciuria
- renal hypomagnesemia type 5 with ocular involvement
- colon adenocarcinoma
role in cell
- transport
- association in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- apical compartment
- cellular membrane
- intercellular junctions
- cell-cell contacts
- tight junctions
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Cldn16 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- calcium-independent cell-cell adhesion
- tight junction assembly
- cell adhesion
- metal ion transport
- cellular cation homeostasis
- intercellular transport
Cellular Component
Where in the cell the gene product is active
- tight junction
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- identical protein binding
- protein binding
- structural molecule activity
- magnesium ion transmembrane transporter activity