Tctex1d2 Gene Summary [Rat]
Predicted to enable dynein intermediate chain binding activity. Predicted to be involved in cilium organization; regulation of cilium assembly; and regulation of intraciliary retrograde transport. Predicted to be located in ciliary base and cytoskeleton. Predicted to be part of cytoplasmic dynein complex. Predicted to be active in cytoplasm. Human ortholog(s) of this gene implicated in asphyxiating thoracic dystrophy. Orthologous to human DYNLT2B (dynein light chain Tctex-type 2B). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Tctex1d2 |
| Official Name | Tctex1 domain containing 2 [Source:RGD Symbol;Acc:1563597] |
| Ensembl ID | ENSRNOG00000001758 |
| Bio databases IDs | |
| Aliases | Tctex1 domain containing 2 |
| Synonyms | 0610012D17Rik, 2410011K15Rik, dynein light chain Tctex-type 2B, RGD1563597, SRTD17, TCTEX1D2 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Tctex1d2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Tctex-1 family
- dynein light chain (DLC)-like domain superfamily
- dynein intermediate chain binding
- protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- short-rib thoracic dysplasia type 17 with or without polydactyly
- digenic short rib thoracic dysplasia 3/6 with polydactyly
- short-rib thoracic dysplasia type 17 with polydactyly
- short-rib thoracic dysplasia 17 without polydactyly
role in cell
- binding in
- assembly
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- centrosome
- axonemes
- microtubule organizing centers
- spindle pole
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Tctex1d2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- cilium morphogenesis
- microtubule-based movement
- intraflagellar retrograde transport
Cellular Component
Where in the cell the gene product is active
- centrosome
- cytoplasmic dynein complex
- interphase microtubule organizing center
- cytoplasm
- spindle pole
- axoneme
Molecular Function
What the gene product does at the molecular level
- protein binding
- dynein intermediate chain binding