Doc2b Gene Summary [Rat]
Enables calcium-dependent phospholipid binding activity. Involved in calcium ion-regulated exocytosis of neurotransmitter; calcium-dependent activation of synaptic vesicle fusion; and positive regulation of calcium ion-dependent exocytosis. Located in plasma membrane. Part of SNARE complex. Is active in glutamatergic synapse. Is extrinsic component of synaptic vesicle membrane. Orthologous to human DOC2B (double C2 domain beta). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Doc2b |
| Official Name | double C2 domain beta [Source:RGD Symbol;Acc:620519] |
| Ensembl ID | ENSRNOG00000060054 |
| Bio databases IDs | |
| Aliases | double C2 domain beta |
| Synonyms | DOC2BL, double C2, beta, double C2 domain beta, double C2 domain β, double C2, β |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Doc2b often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- calcium ion binding
- calcium-dependent phospholipid binding
- protein binding
- Protein kinase C conserved region 2 (CalB)
- transporter
- C2 domain
- syntaxin binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
regulates
- D-glucose
- neurotransmitter
- INS
- cofilin
- insulin
- SLC2A4
role in cell
- invasion
- migration
- priming
- bending
- fusion
- phosphorylation in
- transmission
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- membrane fraction
- glutaminergic synapse
- cellular membrane
- Plasma Membrane
- vesicles
- cytosol
- synaptic vesicles
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Doc2b gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- calcium ion-dependent exocytosis of neurotransmitter
- positive regulation of vesicle fusion
- protein localization
- positive regulation of insulin secretion
- regulation of calcium ion-dependent exocytosis
- positive regulation of calcium ion-dependent exocytosis
- exocytosis
Cellular Component
Where in the cell the gene product is active
- cytoplasm
- SNARE complex
- synapse
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- syntaxin binding
- calcium ion binding
- calcium-dependent phospholipid binding