Slc51a Gene Summary [Rat]
Predicted to enable bile acid transmembrane transporter activity; protein heterodimerization activity; and protein homodimerization activity. Predicted to be involved in bile acid and bile salt transport and bile acid secretion. Located in basolateral plasma membrane. Human ortholog(s) of this gene implicated in progressive familial intrahepatic cholestasis. Orthologous to human SLC51A (solute carrier family 51 member A). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Slc51a |
| Official Name | solute carrier family 51, alpha subunit [Source:RGD Symbol;Acc:1311100] |
| Ensembl ID | ENSRNOG00000001765 |
| Bio databases IDs | |
| Aliases | solute carrier family 51, alpha subunit |
| Synonyms | AV001382, D630035O19Rik, OSTA, OSTalpha, PFIC6, RGD1311100, SLC51A1, solute carrier family 51, alpha subunit, solute carrier family 51 member A, solute carrier family 51, α subunit |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Slc51a often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- protein homodimerization
- protein binding
- bile acid transporter
- Organic solute transporter Ostalpha
- protein heterodimerization
- transporter
Pathways
Biological processes and signaling networks where the Slc51a gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- cholestasis
- primary biliary cirrhosis
- progressive familial intrahepatic cholestasis type 6
- growth failure
- ulcerative colitis
- cholelithiasis
- idiopathic inflammatory myopathy
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- membrane fraction
- intracellular membranes
- cellular membrane
- Endoplasmic Reticulum
- endoplasmic reticulum membrane
- basolateral membrane
- basal membrane
- lateral plasma membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Slc51a gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- transmembrane transport
- bile acid secretion
- bile acid and bile salt transport
Cellular Component
Where in the cell the gene product is active
- endoplasmic reticulum membrane
- membrane
- macromolecular complex
- basolateral plasma membrane
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- bile acid transmembrane transporter activity
- protein binding
- protein homodimerization activity
- protein heterodimerization activity
- transporter activity