Nts Gene Summary [Rat]
Predicted to enable neuropeptide receptor binding activity and receptor ligand activity. Involved in several processes, including cellular response to lithium ion; response to antipsychotic drug; and response to glucocorticoid. Located in axon terminus and neuronal cell body. Used to study nicotine dependence. Biomarker of sciatic neuropathy. Human ortholog(s) of this gene implicated in depressive disorder. Orthologous to human NTS (neurotensin). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Nts |
| Official Name | neurotensin [Source:RGD Symbol;Acc:621612] |
| Ensembl ID | ENSRNOG00000004179 |
| Bio databases IDs | |
| Aliases | neurotensin |
| Synonyms | 5033428E16RIK, Neuromedin N, neurotensin, NmN, NMN-125, NN, NT, NT/N, NTS1 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Nts often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Neurotensin/neuromedin N precursor
- G-protein-coupled receptor binding
- receptor agonist activity
- protein binding
- neuropeptide hormone
Pathways
Biological processes and signaling networks where the Nts gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- epithelial neoplasia
- epithelial cancer
- colon epithelial cancer
- colorectal carcinomagenesis
- colon cancer
- colorectal cancer
- large intestine cancer
- colorectal neoplasia
- intestinal cancer
- abdominal cancer
regulated by
- CG
- docosahexaenoic acid
- oleic acid
- lipopolysaccharide
- tetradecanoylphorbol acetate
- Exendin4
- LEP
- haloperidol
- GW 9508
- bexarotene
role in cell
- growth
- expression in
- apoptosis
- quantity
- proliferation
- differentiation
- formation
- migration
- activation in
- phosphorylation in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Extracellular Space
- intracellular membrane-bounded organelle
- cell surface
- vesicles
- secretory vesicles
- secretory granules
- perikaryon
- axons
- axon terminals
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Nts gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of gene expression
- neuropeptide signaling pathway
- signal transduction
- positive regulation of gene expression
- positive regulation of NF-kappaB transcription factor activity
- positive regulation of protein kinase B signaling cascade
Cellular Component
Where in the cell the gene product is active
- intracellular membrane-bounded organelle
- transport vesicle
- extracellular region
- axon terminus
Molecular Function
What the gene product does at the molecular level
- protein binding
- neuropeptide hormone activity
- receptor agonist activity
- neuropeptide receptor binding