Eif4a2 Gene Summary [Rat]
Predicted to enable ATP hydrolysis activity and translation initiation factor activity. Predicted to be involved in cytoplasmic translational initiation and negative regulation of RNA-dependent RNA polymerase activity. Predicted to act upstream of or within cellular response to leukemia inhibitory factor. Predicted to be located in perinuclear region of cytoplasm. Human ortholog(s) of this gene implicated in neurodevelopmental disorder with hypotonia and speech delay. Orthologous to human EIF4A2 (eukaryotic translation initiation factor 4A2). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Eif4a2 |
| Official Name | eukaryotic translation initiation factor 4A2 [Source:RGD Symbol;Acc:1309225] |
| Ensembl ID | ENSRNOG00000001815 |
| Bio databases IDs | |
| Aliases | eukaryotic translation initiation factor 4A2 |
| Synonyms | 4833432N07Rik, BM-010, DDX2B, DKFZP434M0326, Eif4, EIF4A, eIF-4A-II, EIF4F, eukaryotic translation initiation factor 4A2, NEDHSS |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Eif4a2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- helicase
- helicase superfamily c-terminal domain
- DEAD/DEAH box helicase
- N-terminal helicase domain of the DEAD-box helicase superfamily
- translation initiation factor
- protein binding
- DEAD-like helicases superfamily
- Helicase conserved C-terminal domain
- ATPase
- P-loop containing Nucleoside Triphosphate Hydrolases
- translation regulator
Pathways
Biological processes and signaling networks where the Eif4a2 gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- diabetes mellitus
- renal clear cell adenocarcinoma
- Parkinson disease
- ischemic stroke
- hereditary disorder
- colorectal carcinomagenesis
- neurodevelopmental disorder
- neurodevelopmental disorder with hypotonia and speech delay with or without seizures
- lung adenocarcinoma
- lung adenocarcinoma formation
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- perinuclear region
- cell cortex
- cytosol
- exosomes
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Eif4a2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of RNA-directed RNA polymerase activity
- cytoplasmic translational initiation
- translational initiation
- regulation of translational initiation
Cellular Component
Where in the cell the gene product is active
- perinuclear region of cytoplasm
- eukaryotic translation initiation factor 4F complex
- cytosol
Molecular Function
What the gene product does at the molecular level
- ATPase activity
- translation initiation factor activity
- ATP binding
- RNA binding
- protein binding
- RNA helicase activity
- helicase activity