Ralbp1 Gene Summary [Rat]
Enables GTPase activator activity and small GTPase binding activity. Involved in several processes, including negative regulation of smooth muscle cell proliferation; regulation of intracellular signal transduction; and small GTPase-mediated signal transduction. Is active in Schaffer collateral - CA1 synapse. Human ortholog(s) of this gene implicated in pancreatic adenocarcinoma. Orthologous to human RALBP1 (ralA binding protein 1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Ralbp1 |
| Official Name | ralA binding protein 1 [Source:RGD Symbol;Acc:621134] |
| Ensembl ID | ENSRNOG00000013461 |
| Bio databases IDs | |
| Aliases | ralA binding protein 1 |
| Synonyms | DNP-SG ATPase, ralA binding protein 1, Rik, RIP1, RLIP1, RLIP76 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Ralbp1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- RhoGAP domain
- ATPase activity, coupled to transmembrane movement of substances
- xenobiotic transporter
- Ral binding domain
- enzyme binding
- GTPase activator
- enzyme
- protein binding
- GTPase Activating Protein domain
- GTPase-activator protein for Rho-like GTPases
- RhoGAP
- transporter
Pathways
Biological processes and signaling networks where the Ralbp1 gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- cancer
- metastasis
- obesity
- ovarian cancer
- prostate cancer
- breast carcinoma
- disorder of pregnancy
- renal cell carcinoma
- renal cell cancer
role in cell
- expression in
- migration
- apoptosis
- survival
- invasion
- proliferation
- cell death
- growth
- accumulation in
- development
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- cell surface
- cellular membrane
- Nucleus
- Plasma Membrane
- Mitochondria
- cytosol
- nucleoplasm
- nuclear bodies
- synapse
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Ralbp1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- chemotaxis
- transmembrane transport
- regulation of small GTPase mediated signal transduction
- small GTPase mediated signal transduction
- regulation of GTPase activity
- positive regulation of protein phosphorylation
- doxorubicin transport
- positive regulation of mitochondrial fission
- endocytosis
- regulation of Cdc42 protein signal transduction
- positive regulation of GTPase activity
Cellular Component
Where in the cell the gene product is active
- nuclear body
- membrane
- mitochondrion
- spindle pole
- cytosol
- plasma membrane
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- xenobiotic transporter activity
- ATP binding
- ATPase activity, coupled to transmembrane movement of substances
- protein binding
- glutathione S-conjugate-exporting ATPase activity
- transmembrane transporter activity
- GTPase activator activity
- small GTPase binding
- xenobiotic-transporting ATPase activity