Usp46 Gene Summary [Rat]
Predicted to enable cysteine-type deubiquitinase activity. Involved in regulation of postsynaptic neurotransmitter receptor internalization. Is active in glutamatergic synapse. Orthologous to human USP46 (ubiquitin specific peptidase 46). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Usp46 |
| Official Name | ubiquitin specific peptidase 46 [Source:RGD Symbol;Acc:1564808] |
| Ensembl ID | ENSRNOG00000002106 |
| Bio databases IDs | |
| Aliases | ubiquitin specific peptidase 46 |
| Synonyms | 1190009E20RIK, 2410018I08RIK, FLJ11850, RGD1564808, ubiquitin specific peptidase 46 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Usp46 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- peptidase
- ubiquitin-specific protease
- Ubiquitin carboxyl-terminal hydrolase
- protein binding
- Peptidase_C19
- ubiquitin-like-specific protease
Pathways
Biological processes and signaling networks where the Usp46 gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- glutaminergic synapse
- Cytoplasm
- Nucleus
- cytosol
- synapse
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Usp46 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- protein deubiquitination
- righting reflex
- proteolysis
- adult feeding behavior
- behavioral response to ethanol
- regulation of synaptic transmission, GABAergic
- behavioral fear response
Cellular Component
Where in the cell the gene product is active
- nucleus
- cytoplasm
- cytosol
Molecular Function
What the gene product does at the molecular level
- ubiquitin-specific protease activity
- protein binding
- metal ion binding