Gba Gene Summary [Rat]
Enables glucosylceramidase activity. Involved in several processes, including establishment of skin barrier; response to dexamethasone; and response to testosterone. Predicted to be located in several cellular components, including endoplasmic reticulum; lysosome; and trans-Golgi network. Human ortholog(s) of this gene implicated in Gaucher's disease (multiple); Lewy body dementia; Parkinson's disease (multiple); and Parkinsonism. Orthologous to human GBA1 (glucosylceramidase beta 1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Gba |
| Official Name | glucosylceramidase beta [Source:RGD Symbol;Acc:1589149] |
| Ensembl ID | ENSRNOG00000049281 |
| Bio databases IDs | |
| Aliases | glucosylceramidase beta |
| Synonyms | betaGC, beta GLUCOCEREBROSIDASE, GBA, GC, GCase, GCB, GLUC, GLUCOCEREBROSIDASE, glucosidase, beta, acid, GLUCOSYLCERAMIDASE, glucosylceramidase beta 1, glucosylceramidase β 1, β GLUCOCEREBROSIDASE, β-glucosidase |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Gba often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- steryl-beta-glucosidase
- glucosylceramidase
- scavenger receptor binding
- glucosyltransferase
- Glycosyl hydrolase family 30 TIM-barrel domain
- Glycosyl hydrolase family 30 beta sandwich domain
- enzyme
- protein binding
- receptor binding
- hydrolase
- beta-glucosidase
Pathways
Biological processes and signaling networks where the Gba gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- cancer
- liver neoplasia
- liver cancer
- digestive system cancer
- abdominal cancer
- epithelial cancer
- squamous cell lung cancer
- skin cancer
- breast cancer
- psoriasis
role in cell
- differentiation
- phosphorylation in
- activation
- invasion by
- cell death
- proliferation
- migration
- activation in
- apoptosis
- production in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- stratum corneum lipid matrix
- Extracellular Space
- apical compartment
- perinuclear region
- cellular membrane
- lysosome
- Golgi Apparatus
- Endoplasmic Reticulum
- trans Golgi network
- endosome-lysosome compartments
- lysosome membrane
- lysosomal compartment
- phagosomes
- late endosomal fractions
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Gba gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- microglia differentiation
- lipid storage
- negative regulation of MAP kinase activity
- response to estrogen stimulus
- glucosylceramide catabolic process
- determination of adult lifespan
- pyramidal neuron differentiation
- respiratory electron transport chain
- cholesterol metabolic process
- sphingosine biosynthetic process
- positive regulation of protein complex disassembly
- ceramide biosynthetic process
- brain morphogenesis
- cerebellar Purkinje cell layer formation
- establishment of skin barrier
- negative regulation of neuron apoptotic process
- termination of signal transduction
- response to thyroid hormone stimulus
- autophagy
- antigen processing and presentation
- negative regulation of protein complex assembly
- cellular response to tumor necrosis factor
- response to testosterone stimulus
- neuron apoptotic process
- regulation of TOR signaling cascade
- lysosome organization
- T cell differentiation in thymus
- neuron projection development
- negative regulation of inflammatory response
- neuromuscular process
- response to pH
- cell maturation
- cellular response to starvation
- mitochondrion organization
- negative regulation of interleukin-6 production
- proteasomal ubiquitin-dependent protein catabolic process
- homeostasis of number of cells
- regulation of macroautophagy
- hemopoietic stem cell proliferation
- positive regulation of protein dephosphorylation
- lymphocyte migration
- positive regulation of proteasomal ubiquitin-dependent protein catabolic process
- lipid glycosylation
- response to dexamethasone stimulus
Cellular Component
Where in the cell the gene product is active
- trans-Golgi network
- extracellular vesicular exosome
- endoplasmic reticulum
- lysosomal lumen
- Golgi apparatus
- lysosomal membrane
- lysosome
Molecular Function
What the gene product does at the molecular level
- glucosylceramidase activity
- galactosylceramidase activity
- protein binding
- steryl-beta-glucosidase activity
- glucosyltransferase activity
- receptor binding
- scavenger receptor binding