Srsf6 Gene Summary [Rat]
Predicted to enable mRNA binding activity and pre-mRNA binding activity. Involved in negative regulation of gene expression; negative regulation of type B pancreatic cell apoptotic process; and response to insulin. Predicted to be located in nuclear speck. Predicted to be active in cytoplasm and nucleus. Human ortholog(s) of this gene implicated in proliferative diabetic retinopathy and spermatogenic failure 3. Orthologous to human SRSF6 (serine and arginine rich splicing factor 6). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Srsf6 |
| Official Name | serine and arginine rich splicing factor 6 [Source:RGD Symbol;Acc:1359241] |
| Ensembl ID | ENSRNOG00000006380 |
| Bio databases IDs | |
| Aliases | serine and arginine rich splicing factor 6 |
| Synonyms | 1210001E11Rik, B52, HEL-S-91, serine and arginine-rich splicing factor 6, SFRS6, SRP55 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Srsf6 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- RNA recognition motif (RRM) superfamily
- RNA recognition motif
- protein binding
- RNA binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- schizophrenia
- metastasis
- thoracic aortic aneurysms and dissections
- infection by HIV-1
role in cell
- expression in
- differentiation
- phagocytosis by
- phagocytosis
- cell viability
- proliferation
- translation in
- alternative splicing by
- splicing by
- splicing in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- nuclear fraction
- spliceosomes
- nucleoplasm
- interchromatin granule clusters
- nuclear speckles
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Srsf6 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of keratinocyte differentiation
- response to insulin stimulus
- regulation of wound healing
- regulation of alternative nuclear mRNA splicing, via spliceosome
- regulation of keratinocyte proliferation
- negative regulation of nuclear mRNA splicing, via spliceosome
- alternative nuclear mRNA splicing, via spliceosome
- negative regulation of type B pancreatic cell apoptotic process
- mRNA splice site selection
- positive regulation of epithelial cell proliferation involved in lung morphogenesis
- nuclear mRNA splicing, via spliceosome
Cellular Component
Where in the cell the gene product is active
- nuclear speck
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- pre-mRNA binding
- protein binding
- RNA binding