Corin Gene Summary [Rat]
Predicted to enable serine-type endopeptidase activity. Involved in regulation of blood pressure and regulation of renal sodium excretion. Located in cytoplasmic vesicle and plasma membrane. Biomarker of congestive heart failure. Human ortholog(s) of this gene implicated in familial hypertrophic cardiomyopathy; hypertension; and pre-eclampsia. Orthologous to human CORIN (corin, serine peptidase). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Corin |
| Official Name | corin, serine peptidase [Source:RGD Symbol;Acc:727887] |
| Ensembl ID | ENSRNOG00000002302 |
| Bio databases IDs | |
| Aliases | corin, serine peptidase |
| Synonyms | ATC2, CMH30, corin, serine peptidase, CRN, LOC289596, Lrp4, PEE5, TMPRSS10 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Corin often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Scavenger receptor cysteine-rich domain
- extracellular domain
- activation domain
- Trypsin-like serine protease
- Tryp_SPc
- catalytic domain
- peptidase
- Fz domain
- protein binding
- Scavenger receptor Cys-rich
- CRD_domain cysteine-rich domain, also known as Fz (frizzled) domain
- endopeptidase
- trypsin
- serine endopeptidase
- transmembrane domain
- active site
- LDLa
- SRCR domain
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- HER2 negative hormone receptor negative breast cancer
- uterine leiomyoma
- leiomyomatosis
- opioid dependence
- hypopituitarism
- preeclampsia/eclampsia 5
- androgenic alopecia
- weight gain
- oral squamous cell carcinoma
- squamous cell cancer of the oral cavity
role in cell
- activation in
- differentiation
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- cell surface
- cellular membrane
- actin cytoskeleton
- nuclear bodies
- cytoplasmic vesicles
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Corin gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- regulation of systemic arterial blood pressure by atrial natriuretic peptide
- female pregnancy
- regulation of renal sodium excretion
- peptide hormone processing
- regulation of blood pressure
Cellular Component
Where in the cell the gene product is active
- nuclear body
- actin cytoskeleton
- extracellular region
- plasma membrane
- cell surface
Molecular Function
What the gene product does at the molecular level
- protein binding
- endopeptidase activity
- serine-type endopeptidase activity