Sgcd Gene Summary [Rat]
Predicted to be involved in cardiac muscle tissue development and heart contraction. Predicted to act upstream of or within several processes, including calcium-mediated signaling; cardiac muscle cell contraction; and heart development. Predicted to be located in plasma membrane and sarcoplasmic reticulum. Predicted to be part of sarcoglycan complex. Predicted to be active in sarcolemma. Human ortholog(s) of this gene implicated in autosomal recessive limb-girdle muscular dystrophy type 2F; dilated cardiomyopathy 1L; and muscular dystrophy. Orthologous to human SGCD (sarcoglycan delta). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Sgcd |
| Official Name | sarcoglycan, delta [Source:RGD Symbol;Acc:1306638] |
| Ensembl ID | ENSRNOG00000002372 |
| Bio databases IDs | |
| Aliases | sarcoglycan, delta |
| Synonyms | 35DAG, A530047J11Rik, CMD1L, DAGD, delta-SG, Deta sacroglycan, LGMDR6, SARCOGLYCAN, sarcoglycan delta, sarcoglycan, delta, sarcoglycan, delta (dystrophin-associated glycoprotein), Sarcoglycan δ, sarcoglycan, δ, sarcoglycan, δ (dystrophin-associated glycoprotein), Scgd, SGCDP, SGD, SG-delta, SG-δ, δ sarcoglycan, δ-SG |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Sgcd often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- intracellular domain
- Sarcoglycan complex subunit protein
- protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- limb-girdle muscular dystrophy type 2F
- non-insulin-dependent diabetes mellitus
- cardiac fibrosis
- limb-girdle muscular dystrophy type 2
- dilated cardiomyopathy type 1L
- fibrosis
- coronary artery disease
- cleft palate
- congenital hydrocephalus
- COVID-19
role in cell
- cell death
- area
- integrity
- contraction by
- organization
- density
- development
- structural integrity
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- microsomal fraction
- Plasma Membrane
- sarcoplasmic reticulum
- endoplasmic reticulum membrane
- microsome
- Golgi membrane
- sarcolemma
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Sgcd gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- muscle organ development
- cardiac muscle cell contraction
- protein complex localization
- heart contraction
- calcium ion homeostasis
- cardiac muscle cell development
- coronary vasculature morphogenesis
- calcium-mediated signaling
- cardiac muscle tissue development
Cellular Component
Where in the cell the gene product is active
- cytoskeleton
- sarcoplasmic reticulum
- sarcolemma
- dystrophin-associated glycoprotein complex
- sarcoglycan complex
- plasma membrane