Sgce Gene Summary [Rat]
Involved in kidney development and skeletal muscle tissue development. Predicted to be located in Golgi apparatus and dendrite membrane. Predicted to be part of sarcoglycan complex. Human ortholog(s) of this gene implicated in myoclonic dystonia 11. Orthologous to human SGCE (sarcoglycan epsilon). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Sgce |
| Official Name | sarcoglycan, epsilon [Source:RGD Symbol;Acc:1303201] |
| Ensembl ID | ENSRNOG00000046905 |
| Bio databases IDs | |
| Aliases | sarcoglycan, epsilon |
| Synonyms | DYT11, epsilon-SG, ESG, sarcoglycan epsilon, sarcoglycan, epsilon, sarcoglycan ε, sarcoglycan, ε, ε sarcoglycan, ε-SG |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Sgce often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Sarcoglycan alpha/epsilon
- X25 domain of Bacillus acidopullulyticus pullulanase and similar proteins
- Cadherin repeat-like domain
- protein binding
- Dystroglycan-type cadherin-like domains
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- endometriosis
- myoclonic dystonia type 11
- schizophrenia
- covid-19 death
- hereditary disorder
- myoclonus
- insomnia
- movement disorder
role in cell
- expression in
- phosphorylation in
- colony formation
- binding in
- adhesion
- abnormal morphology
- sphere formation
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- cell surface
- Nucleus
- Golgi Apparatus
- endoplasmic reticulum membrane
- microsome
- Golgi membrane
- sarcolemma
- dendrites
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Sgce gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- muscle organ development
- cell-matrix adhesion
Cellular Component
Where in the cell the gene product is active
- dendrite membrane
- cytoskeleton
- sarcolemma
- dystrophin-associated glycoprotein complex
- sarcoglycan complex
- Golgi apparatus
- plasma membrane