Sgcg Gene Summary [Rat]
Predicted to be involved in cardiac muscle tissue development and heart contraction. Predicted to act upstream of or within gene expression. Predicted to be located in plasma membrane. Predicted to be part of sarcoglycan complex. Predicted to be active in sarcolemma. Human ortholog(s) of this gene implicated in autosomal recessive limb-girdle muscular dystrophy type 2C and type 2 diabetes mellitus. Orthologous to human SGCG (sarcoglycan gamma). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Sgcg |
| Official Name | sarcoglycan, gamma [Source:RGD Symbol;Acc:1359577] |
| Ensembl ID | ENSRNOG00000014603 |
| Bio databases IDs | |
| Aliases | sarcoglycan, gamma |
| Synonyms | 35DAG, 5430420E18RIK, A4, DAGA4, DMDA, DMDA1, Gamma sacroglycan, gamma SARCOGLYCAN, gamma-SG, Gsg, LGMD2C, LGMDR5, MAM, sarcoglycan gamma, sarcoglycan, gamma, sarcoglycan, gamma (dystrophin-associated glycoprotein), Sarcoglycan γ, sarcoglycan, γ, sarcoglycan, γ (dystrophin-associated glycoprotein), SCARMD2, SCG3, γ sacroglycan, γ SARCOGLYCAN, γ-SG |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Sgcg often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- intracellular domain
- Sarcoglycan complex subunit protein
- protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- ovarian carcinoma
- acute myeloid leukemia
- dystrophy
- limb-girdle muscular dystrophy type 2C
- asthma
- growth failure
- limb-girdle muscular dystrophy type 2
- diabetic peripheral neuropathy
- major depression
- alcoholism
role in cell
- apoptosis
- organization
- size
- morphology
- function
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- microsomal fraction
- endoplasmic reticulum membrane
- microsome
- sarcolemma
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Sgcg gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- muscle organ development
- heart contraction
- gene expression
- cardiac muscle tissue development
Cellular Component
Where in the cell the gene product is active
- cytoskeleton
- cytoplasm
- sarcolemma
- sarcoglycan complex
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- protein binding