Gnl3l Gene Summary [Rat]
Predicted to enable GTP binding activity. Predicted to be involved in several processes, including negative regulation of protein modification by small protein conjugation or removal; negative regulation of telomere maintenance via telomerase; and positive regulation of protein localization to chromosome, telomeric region. Predicted to be located in cytosol and nucleoplasm. Predicted to be part of telomerase holoenzyme complex. Predicted to be active in nucleolus. Orthologous to human GNL3L (G protein nucleolar 3 like). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Gnl3l |
| Official Name | G protein nucleolar 3 like [Source:RGD Symbol;Acc:1600217] |
| Ensembl ID | ENSRNOG00000002509 |
| Bio databases IDs | |
| Aliases | G protein nucleolar 3 like |
| Synonyms | GNL3B, G protein nucleolar 3 like, guanine nucleotide binding protein nucleolar 3 like, LOC107985712 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Gnl3l often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- GTP binding domain
- intermediate domain
- ribosome biogenesis GTP-binding protein YlqF
- protein binding
- Circularly permuted YlqF-related GTPases
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- chronic obstructive pulmonary disease
- stomach neoplasm
- colorectal neoplasia
- gastrointestinal neoplasia
- alopecia
- malignant neoplasm of esophagus
- esophageal cancer
- colorectal neoplasm
role in cell
- expression in
- phosphorylation in
- activation in
- cell viability
- G2/M phase
- downregulation in
- ubiquitination in
- stabilization in
- shortening in
- shortening
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- cytosol
- nucleoplasm
- nucleoli
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Gnl3l gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- regulation of protein stability
- ribosome biogenesis
- negative regulation of protein sumoylation
- negative regulation of telomere maintenance via telomerase
- negative regulation of protein ubiquitination
- negative regulation of protein binding
- positive regulation of protein complex assembly
Cellular Component
Where in the cell the gene product is active
- membrane
- cytosol
- telomerase holoenzyme complex
- nucleolus
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- GTP binding
- protein binding
- RNA binding