Prkab2 Gene Summary [Rat]
Enables protein kinase binding activity. Predicted to be involved in cellular response to nutrient levels; positive regulation of cold-induced thermogenesis; and signal transduction. Located in apical plasma membrane and cytoplasm. Part of cAMP-dependent protein kinase complex and nucleotide-activated protein kinase complex. Orthologous to human PRKAB2 (protein kinase AMP-activated non-catalytic subunit beta 2). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Prkab2 |
| Official Name | protein kinase AMP-activated non-catalytic subunit beta 2 [Source:RGD Symbol;Acc:620905] |
| Ensembl ID | ENSRNOG00000018166 |
| Bio databases IDs | |
| Aliases | protein kinase AMP-activated non-catalytic subunit beta 2 |
| Synonyms | 5730553K21Rik, AMPK beta2, protein kinase, AMP-activated, beta 2 non-catalytic subunit, protein kinase AMP-activated non-catalytic subunit beta 2, protein kinase AMP-activated non-catalytic subunit β 2, protein kinase, AMP-activated, β 2 non-catalytic subunit |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Prkab2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- kinase
- E_set
- Glycogen recognition site of AMP-activated protein kinase
- protein kinase binding
- 5'-AMP-activated protein kinase beta subunit, interaction domain
- enzyme binding
- protein binding
- SNF1A/AMP-activated protein kinase
Pathways
Biological processes and signaling networks where the Prkab2 gene in rat plays a role, providing insight into its function and relevance in health or disease.
- AMPK Signaling
- Apelin Adipocyte Signaling Pathway
- Apelin Cardiac Fibroblast Signaling Pathway
- Apelin Endothelial Signaling Pathway
- Apelin Muscle Signaling Pathway
- Apelin Pancreas Signaling Pathway
- Autophagy
- Chronic Myeloid Leukemia Signaling
- Circadian Rhythm Signaling
- Docosahexaenoic Acid (DHA) Signaling
- Endocannabinoid Cancer Inhibition Pathway
- eNOS Signaling
- Epithelial Adherens Junction Signaling
- Estrogen Receptor Signaling
- Glucocorticoid Receptor Signaling
- IL-10 Signaling
- IL-12 Signaling and Production in Macrophages
- Mitochondrial Dysfunction
- mTOR Signaling
- Osteoarthritis Pathway
- PPARα/RXRα Activation
- Type II Diabetes Mellitus Signaling
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- muscle weakness
- insulin resistance
- obesity
- exercise intolerance
- congenital hypothyroidism
- intellectual disability and developmental delay
- colorectal adenocarcinoma
- colorectal carcinomagenesis
role in cell
- apoptosis
- quantity
- uptake by
- size
- aggregation
- necrosis
- area
- cleavage
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- cytosol
- apical membrane
- nucleoplasm
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Prkab2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- cellular response to nutrient levels
- signal transduction
- fatty acid biosynthetic process
Cellular Component
Where in the cell the gene product is active
- nucleus
- cytoplasm
- cytosol
- nucleoplasm
- AMP-activated protein kinase complex
Molecular Function
What the gene product does at the molecular level
- protein kinase binding
- protein binding
- AMP-activated protein kinase activity