Edaradd Gene Summary [Rat]
Involved in positive regulation of non-canonical NF-kappaB signal transduction. Used to study hypohidrotic ectodermal dysplasia and otitis media. Human ortholog(s) of this gene implicated in ectodermal dysplasia 11A and ectodermal dysplasia 11B. Orthologous to human EDARADD (EDAR associated via death domain). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Edaradd |
| Official Name | EDAR-associated death domain [Source:RGD Symbol;Acc:1564010] |
| Ensembl ID | ENSRNOG00000002624 |
| Bio databases IDs | |
| Aliases | EDAR-associated death domain |
| Synonyms | 1810032E07Rik, 5830469M23Rik, A630043P06, CR, CRINKLED, ECTD11A, ECTD11B, ED3, EDA3, EDAR associated via death domain, RGD1564010 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Edaradd often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Death domain
- protein binding
- Death Domain Superfamily of protein-protein interaction domains
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- insomnia
- autosomal recessive hypohidrotic/hair/tooth type ectodermal dysplasia type 11B
- cleft lip
- autosomal dominant hypohidrotic/hair/tooth type ectodermal dysplasia type 11B
- autosomal dominant hypohidrotic/hair/tooth type ectodermal dysplasia type 11A
- hypohidrotic ectodermal dysplasia
- endometrioma
- hypothyroidism
- X-linked immunodeficiency with magnesium defect, Epstein-Barr virus infection and neoplasia
- Christ-Siemens-Touraine syndrome
regulates
- NFkB (complex)
role in cell
- activation in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- cytosol
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Edaradd gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- signal transduction
- cell differentiation
Cellular Component
Where in the cell the gene product is active
- cytosol
Molecular Function
What the gene product does at the molecular level
- protein binding