Edaradd Gene Summary [Mouse]
Predicted to enable death receptor binding activity. Acts upstream of or within hair follicle development; odontogenesis of dentin-containing tooth; and trachea gland development. Predicted to be located in cytoplasm. Is expressed in several structures, including alimentary system; metanephros; naris; skin; and ureter. Human ortholog(s) of this gene implicated in ectodermal dysplasia 11A and ectodermal dysplasia 11B. Orthologous to human EDARADD (EDAR associated via death domain). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Edaradd |
| Official Name | EDAR (ectodysplasin-A receptor)-associated death domain [Source:MGI Symbol;Acc:MGI:1931001] |
| Ensembl ID | ENSMUSG00000095105 |
| Bio databases IDs | |
| Aliases | EDAR (ectodysplasin-A receptor)-associated death domain |
| Synonyms | 1810032E07Rik, 5830469M23Rik, A630043P06, CR, CRINKLED, ECTD11A, ECTD11B, ED3, EDA3, EDAR associated via death domain, RGD1564010 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Edaradd often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Death domain
- protein binding
- Death Domain Superfamily of protein-protein interaction domains
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
regulates
- NFkB (complex)
disease
- insomnia
- autosomal recessive hypohidrotic/hair/tooth type ectodermal dysplasia type 11B
- cleft lip
- autosomal dominant hypohidrotic/hair/tooth type ectodermal dysplasia type 11B
- autosomal dominant hypohidrotic/hair/tooth type ectodermal dysplasia type 11A
- hypohidrotic ectodermal dysplasia
- endometrioma
- hypothyroidism
- X-linked immunodeficiency with magnesium defect, Epstein-Barr virus infection and neoplasia
- Christ-Siemens-Touraine syndrome
phenotypes
- Purkinje cell degeneration
- abnormal brain morphology
- abnormal cerebellar layer morphology
- abnormal cerebellum fissure morphology
- abnormal cerebellum morphology
- abnormal coat appearance
- abnormal coat/ hair morphology
- abnormal coat/hair pigmentation
- abnormal cornea morphology
- abnormal enamel morphology
- abnormal epidermal layer morphology
- abnormal eyelid morphology
- abnormal hair follicle development
- abnormal hair growth
- abnormal hair texture
- abnormal incisor morphology
- abnormal lipid level
- abnormal locomotor coordination
- abnormal maternal nurturing
- abnormal molar cusp morphology
- abnormal myelination
- abnormal outer ear morphology
- abnormal respiration
- abnormal respiratory mucosa morphology
- abnormal respiratory sounds
- abnormal skin morphology
- abnormal skin pigmentation
- abnormal tail morphology
- abnormal tail position or orientation
- abnormal tail ring morphology
- abnormal tooth morphology
- absent Meibomian glands
- absent guard hair
- absent zigzag hairs
- anemia
- big ears
- cornea ulcer
- corneal opacity
- decreased body size
- decreased body weight
- decreased eyelid cilium number
- decreased hair follicle number
- decreased litter size
- decreased molar number
- delayed hair appearance
- demyelination
- focal hair loss
- kinked tail
- narrow eye opening
- pallor
- postnatal growth retardation
- postnatal lethality
- premature death
- reduced female fertility
- reduced fertility
- short hair
- small cerebellum
- small molars
- sparse hair
- thin dermal layer
- thin skin
- underdeveloped hair follicles
role in cell
- activation in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- cytosol
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Edaradd gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- signal transduction
- cell differentiation
Cellular Component
Where in the cell the gene product is active
- cytosol
Molecular Function
What the gene product does at the molecular level
- protein binding