Edar Gene Summary [Rat]
Predicted to enable transmembrane signaling receptor activity. Predicted to be involved in cytokine-mediated signaling pathway; positive regulation of JNK cascade; and positive regulation of canonical NF-kappaB signal transduction. Predicted to act upstream of or within several processes, including hair follicle development; positive regulation of non-canonical NF-kappaB signal transduction; and salivary gland cavitation. Predicted to be located in apical part of cell. Predicted to be active in plasma membrane. Human ortholog(s) of this gene implicated in ectodermal dysplasia 10A and ectodermal dysplasia 10B. Orthologous to human EDAR (ectodysplasin A receptor). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Edar |
| Official Name | ectodysplasin-A receptor [Source:RGD Symbol;Acc:1561714] |
| Ensembl ID | ENSRNOG00000028598 |
| Bio databases IDs | |
| Aliases | ectodysplasin-A receptor |
| Synonyms | DL, ECTD10A, ECTD10B, ectodysplasin-A receptor, ED1R, ED3, ED5, EDA1R, EDA3, EDA-A1R, HRM1, LOC678867, RGD1561714 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Edar often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- extracellular domain
- signaling receptor activity
- ectodomain
- intracellular domain
- protein binding
- cytosolic tail domain
- Tumor necrosis factor receptor superfamily (TNFRSF)
- Death Domain Superfamily of protein-protein interaction domains
- transmembrane receptor
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- autosomal dominant hypohidrotic/hair/nail type ectodermal dysplasia type 10A
- hereditary disorder
- autosomal recessive hypohidrotic/hair/tooth type ectodermal dysplasia type 10B
- nonsyndromic tooth agenesis
- male pattern hair loss
- androgenic alopecia
- hypohidrotic ectodermal dysplasia
- autosomal dominant hypohidrotic/hair/tooth type ectodermal dysplasia type 10A
- autosomal recessive hypohidrotic/hair/tooth type ectodermal dysplasia type 11B
- ectodermal dysplasia
role in cell
- apoptosis
- activation in
- proliferation
- cell death
- survival
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- apical compartment
- cellular membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Edar gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- salivary gland cavitation
- hair follicle development
- cytokine-mediated signaling pathway
- positive regulation of JNK cascade
- positive regulation of gene expression
- pigmentation
- apoptotic process
- epidermis development
- positive regulation of I-kappaB kinase/NF-kappaB cascade
- cell differentiation
- odontogenesis of dentin-containing tooth
Cellular Component
Where in the cell the gene product is active
- apical part of cell
- membrane
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- protein binding
- transmembrane signaling receptor activity
- signaling receptor activity